Partyka, C M Gelardi, N L Fadden, K Rifai, A Gruppuso, P A Oh, W Reddy, G S
Published in
Biology of the neonate
1a,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the hormonal form of vitamin D3, has been shown to play a role in the regulation of growth of the regenerating adult rat liver following partial hepatectomy. In addition, a recent study implicated the neonatal liver as a possible extrarenal site of 1,25(OH)2D3 synthesis. Therefore, in our present study we us...
Guajardo, L Beharry, K D Modanlou, H D Aranda, J V
Published in
Biology of the neonate
Ascorbic acid (AA) is a powerful antioxidant required for the defense against oxidative stress. At present it is not known whether AA may play a role in the developmental process of the fetus. We therefore determined the relationship of AA levels between the umbilical cord vein (UCV) and umbilical cord artery (UCA) of preterm ( or = 37 weeks of ge...
Dimberg, J Lilja, I Weström, B Tagesson, C Söderkvist, P Gustafson-Svärd, C
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Biology of the neonate
Phospholipase A2 (PLA2) activity is important in the gastrointestinal tract, but detailed information about the different PLA2 isoenzymes present in the gastrointestinal mucosa is yet lacking. In the present study, we have investigated the postnatal development of group II phospholipase A2 (PLA2 II) gene expression in the forestomach, glandular sto...
Jain, L DelValle, J Gelhar, D Levy, P McCulloch, K Vidyasagar, D
Published in
Biology of the neonate
To determine the chronology of postnatal somatostatin (SRIF) changes in preterm infants and the relationship of SRIF levels to respiratory and gastrointestinal complications, we evaluated sequential SRIF levels in 62 preterm infants in the first month of life. Weekly preprandial plasma samples were obtained and analyzed for SRIF using a radioimmuno...
Chattopadhyay, N Kher, R Virmani, J Godbole, M M
Published in
Biology of the neonate
One of the most alarming observations of iodine deficiency disorders (IDD) is neurological cretinism which is caused due to lack of T3 during the crucial stages of brain development. We have developed an iodine-deficient rat model to study the pattern of T3 receptor genes expression in the brain during postnatal development under iodine deficiency....
McCaffrey, M J Bose, C L Reiter, P D Stiles, A D
Published in
Biology of the neonate
Nitric oxide (NO) is thought to be a primary mediator of the reduction in pulmonary vascular resistance which occurs in the newborn period. L-arginine is the precursor for the formation of nitric oxide in the pulmonary endothelium. Low serum arginine levels have been reported in infants with persistent pulmonary hypertension of the newborn (PPHN). ...
Straussberg, R Sirota, L Hart, J Amir, Y Djaldetti, M Bessler, H
Published in
Biology of the neonate
The effect of colostrum of mothers of preterm and full-term newborns on the phagocytic activity for latex particles by normal peripheral blood polymorphonuclear cells was examined. The results showed that human colostrum contains a phagocytosis-promoting factor(s), which not only increases the number of phagocytic cells, but also stimulates the pha...
Wallenius, K
Published in
Biology of the neonate
Pereira, M R Reis, F C Landriault, L Cates, D B Rigatto, H
Published in
Biology of the neonate
To determine the changes in alveolar PCO2 (PACO2) and PO2 (PAO2) during periodic and regular breathing epochs in the same infants, we studied 11 preterm infants during quiet sleep (birth weight 1,630 +/- 94 g; gestational age 31 +/- 1 weeks; postnatal age 32 +/- 3 days). A total of 94 breathing/apneic cycles were analyzed and compared with regular ...
Hansen, T W Cashore, W J
Published in
Biology of the neonate
The mechanism for the preferential distribution of bilirubin to basal ganglia ('kernicterus') is unknown. We hypothesized that differences in bilirubin clearance rates between brain regions might explain this phenomenon. Bilirubin [30 mg/kg over 5 min, with 370-740 kBq (10-20 mu Ci) tritiated bilirubin] was infused into a peripheral vein in unanest...
