Singh, Vishal Sagar, Poonam Kaul, Sunaina Sandhir, Rajat Singhal, Nitin Kumar
Published in
Bioconjugate chemistry
Metabolic disorders have been increasing at an alarming rate, and one such example of metabolic disorder is type 2 diabetes mellitus (T2DM). Unregulated gluconeogenesis in T2DM results in increased hepatic glucose output that causes fasting and postprandial hyperglycaemia. Extensive proofs have shown that the downregulation of the key rate-limiting...
Ardini, Matteo Bellelli, Andrea Williams, David L Di Leandro, Luana Giansanti, Francesco Cimini, Annamaria Ippoliti, Rodolfo Angelucci, Francesco
Published in
Bioconjugate chemistry
Morpheeins are proteins that reversibly assemble into different oligomers, whose architectures are governed by conformational changes of the subunits. This property could be utilized in bionanotechnology where the building of nanometric and new high-ordered structures is required. By capitalizing on the adaptability of morpheeins to create patterne...
Lim, Seungho Kim, Woojun Song, Sukyung Shim, Man Kyu Yoon, Hong Yeol Kim, Byung-Soo Kwon, Ick Chan Kim, Kwangmeyung
Published in
Bioconjugate chemistry
Nanoparticles have been used for effectively delivering imaging agents and therapeutic drugs into stem cells. However, nanoparticles are not sufficiently internalized into stem cells; thus, new delivery method of nanoparticles into stem cells is urgently needed. Herein, we develop bicyclo[6.1.0]nonyne (BCN)-conjugated gold nanoparticles (BCN-AuNPs)...
Noteborn, Willem E M Abendstein, Leoni Sharp, Thomas H
Published in
Bioconjugate chemistry
DNA origami nanostructures generally require a single scaffold strand of specific length, combined with many small staple strands. Ideally, the length of the scaffold strand should be dictated by the size of the designed nanostructure. However, synthesizing arbitrary-length single-stranded DNA in sufficient quantities is difficult. Here, we describ...
Sayers, Jessica Wralstad, Evans C. Raines, Ronald T.
Published in
Bioconjugate chemistry
Choi, Sang-Kee Rho, Jungi Yoon, Sang Eun Seok, Jin-Hong Kim, Hyungi Min, Junsik Yoon, Woojin Lee, Sanghee Yun, Hoseop Kwon, O-Pil
...
Published in
Bioconjugate chemistry
By taking advantage of a unique mechanism of aggregation-induced emission (AIE) phenomena, AIE luminogens (AIEgens) have been provided as a solution to overcome the limitations of conventional fluorophores bearing the feature of aggregation-caused quenching (ACQ) phenomena. Especially, AIEgens paved the way to develop fluorogenic probes ideal for f...
Solomatina, Anastasia I Slobodina, Aleksandra D Ryabova, Elena V Bolshakova, Olga I Chelushkin, Pavel S Sarantseva, Svetlana V Tunik, Sergey P
Published in
Bioconjugate chemistry
Herein we report on the synthesis, structural characterization and photophysical properties of cyclometalated Pt(II) complexes [Pt(N^C)(PPh2(C6H4COOH))Cl] (where N^C ligands are 2-phenylpyridine, (2-benzofuran-3-yl)pyridine, and (2-benzo[b]tiophen-3-yl)pyridine) and their conjugates with the histidine-containing RRRRRRRRRRHVLPKVQA peptide. This pep...
Park, Yong Dae Park, Jam-Eon Kim, Hyeon Sik Choi, Seung-Hyeon Park, Jung Eun Jeon, Jongho Park, Seung-Hwan
Published in
Bioconjugate chemistry
Dual-modular imaging approaches combining near-infrared (NIR) fluorescence (FLI) and photoacoustic imaging (PAI) require suitable contrast agents to produce dual-modular signals. Although nanoparticles have been used to develop PAI agents, small molecule-based imaging agents have not been extensively studied, highlighting the need to design new flu...
Maeda, Yusuke Sawada, Toshiki Takahashi, Tsuyoshi Yuasa, Hideya Mihara, Hisakazu
Published in
Bioconjugate chemistry
Saccharides are well-known to play important roles in various biological events through specific interactions with target molecules such as carbohydrate-binding proteins (so-called lectins). Although characterization and identification of lectin molecules with saccharides are essential to understand biological events, they are still difficult due t...
Swierczynski, Michael J Ball, Zachary T
Published in
Bioconjugate chemistry
Polymer-protein conjugates are hybrid materials with interesting and useful properties. Methods to prepare diverse diblock materials of this sort often struggle to deal with the complexity and size of reagents, and so polymer-protein conjugation represents a stringent testing ground for nontraditional bioconjugation methods, such as metal-catalyzed...
