Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types
Published in Biochimie in Nov 01, 2015
Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types
Published in Biochimie in Nov 01, 2015
Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types
Published in Biochimie in Nov 01, 2015
Activation of p53 mediated glycolytic inhibition-oxidative stress-apoptosis pathway in Dalton's lymphoma by a ruthenium ...
Published in Biochimie in March 2015
There is a general agreement that most of the cancer cells switch over to aerobic glycolysis (Warburg effect) and upregulate antioxidant enzymes to prevent oxidative stress induced apoptosis. Thus, there is an evolving view to target these metabolic alterations by novel anticancer agents to restrict tumor progression in vivo. Previously we have rep...
Morin, a dietary flavonoid, exhibits anti-fibrotic effect and induces apoptosis of activated hepatic stellate cells by s...
Published in Biochimie in March 2015
In experimental liver fibrosis, activated hepatic stellate cells (HSCs) play a central role and thus, induction of apoptosis of activated HSCs is a promising therapeutic strategy for liver fibrosis. The present study was designed to elucidate the molecular mechanisms of the pro-apoptotic effects of morin, a dietary flavonoid, in vitro and in vivo...
Insight into the structural flexibility and function of Mycobacterium tuberculosis isocitrate lyase.
Published in Biochimie in March 2015
Isocitrate lyase (ICL), is a key enzyme of the glyoxylate shunt crucial for the survival of Mycobacterium tuberculosis (Mtb) in macrophages during persistent infection. MtbICL catalyses the first step of this carbon anaplerosis cycle and is considered as a potential anti-tubercular drug target. The MtbICL is a tetramer with 222 symmetry, and each s...
Combination of carvacrol and rosiglitazone ameliorates high fat diet induced changes in lipids and inflammatory markers ...
Published in Biochimie in March 2015
Type 2 diabetes mellitus is a chronic metabolic disease with the highest rates of prevalence and mortality worldwide. Hyperlipidemia has been ranked as one of the greatest risk factors. This study was undertaken to evaluate the antihyperlipidemic and anti-inflammatory effect of carvacrol (CVL) and rosiglitazone (RSG) combination on diabetic mice. H...
3,4-Methylenedioxy-β-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppr...
Published in Biochimie in March 2015
Triple negative breast cancer (TNBC) exhibits an aggressive clinical course by high metastatic potential. It is known that integrin-mediated cell adhesion and migration are important for cancer metastasis. In the present study, a synthetic compound, 3, 4-methyenedioxy-β-nitrostyrene (MNS), significantly inhibited adhesion of TNBC cell lines to dif...
Anticoagulant mechanism and platelet deaggregation property of a non-cytotoxic, acidic phospholipase A2 purified from In...
Published in Biochimie in March 2015
In the present study, anticoagulant and platelet modulating activities of an acidic phospholipase A2 (NnPLA2-I) purified from Indian cobra Naja naja venom was investigated. The NnPLA2-I displayed a mass of 15.2 kDa and 14,186.0 Da when analyzed by SDS-PAGE and MALDI-TOF-MS, respectively. Peptide mass fingerprinting analysis of the NnPLA2-I showed i...
Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNO...
Published in Biochimie in March 2015
Epigenetic modifications are increasingly recognized to play a significant contribution in diabetic nephropathy (DN). Histone deacetylases (HDACs) are the emerging target in the pathogenesis and progression of DN. Valproic acid (VPA), a widely used anti-epileptic drug and has been proven as an HDAC inhibitor. This study was aimed to evaluate the pr...