Kenoth, Roopa Zou, Xianqiong Simanshu, Dhirendra K Pike, Helen M Malinina, Lucy Patel, Dinshaw J Brown, Rhoderick E Kamlekar, Ravi Kanth
Published in
Biochimica et biophysica acta. Biomembranes
HET-C2 is a fungal glycolipid transfer protein (GLTP) that uses an evolutionarily-modified GLTP-fold to achieve more focused transfer specificity for simple neutral glycosphingolipids than mammalian GLTPs. Only one of HET-C2's two Trp residues is topologically identical to the three Trp residues of mammalian GLTP. Here, we provide the first assessm...
Liu, Miao Hoskins, Amanda Verma, Nirmal Bers, Donald M Despa, Sanda Despa, Florin
Published in
Biochimica et biophysica acta. Molecular basis of disease
Amylin is a pancreatic β-cell hormone co-secreted with insulin, plays a role in normal glucose homeostasis, and forms amyloid in the pancreatic islets of individuals with type-2 diabetes. Aggregated amylin is also found in blood and extra-pancreatic tissues, including myocardium. Myocardial amylin accumulation is associated with myocyte Ca2+ dysreg...
Choudhary, Mayur Safe, Stephen Malek, Goldis
Published in
Biochimica et biophysica acta. Molecular basis of disease
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor, initially discovered for its role in regulating xenobiotic metabolism. There is extensive evidence supporting a multi-faceted role for AhR, modulating physiological pathways important in cell health and disease. Recently we demonstrated that the AhR plays a role in the ...
Shin, Hyewon He, Minzhen Yang, Zhi Jeon, Yong Heui Pfleger, Jessica Sayed, Danish Abdellatif, Maha
Published in
Biochimica et biophysica acta. Gene regulatory mechanisms
The mechanisms that regulate H2A.Z and its requirement for transcription in differentiated mammalian cells remains ambiguous. In this study, we identified the interaction between the C-terminus of ANP32e and N-terminus of H2A.Z in a yeast two-hybrid screen. Knockdown of ANP32e resulted in proteasomal degradation and nuclear depletion of H2A.Z or of...
Murali, Ranjani Gennis, Robert B.
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Biochimica et biophysica acta
Pizzo, Elio Pane, Katia Bosso, Andrea Landi, Nicola Ragucci, Sara Russo, Rosita Gaglione, Rosa Torres, Marcelo D T de la Fuente-Nunez, Cesar Arciello, Angela
...
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Biochimica et biophysica acta
Antimicrobial peptides, also called Host Defence Peptides (HDPs), are effectors of innate immune response found in all living organisms. In a previous report, we have identified by chemical fragmentation, and characterized the first cryptic antimicrobial peptide in PD-L4, a type 1 ribosome inactivating protein (RIP) from leaves of Phytolacca dioica...
Ruvolo, Peter P. Ruvolo, Vivian R. Burks, Jared K. Qiu, YiHua Wang, Rui-Yu Shpall, Elizabeth J. Mirandola, Leonardo Hail, Numsen Jr. Zeng, Zhihong McQueen, Teresa
...
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Biochimica et biophysica acta
In acute myeloid leukemia (AML), high Galectin 3 (LGALS3) expression is associated with poor prognosis. The role of LGALS3 derived from mesenchymal stromal cells (MSC) in the AML microenvironment is unclear; however, we have recently found high LGALS3 expression in MSC derived from AML patients is associated with relapse. In this study, we used rev...
Wang, Yifeng Ding, Wen-Xing Li, Tiangang
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Biochimica et biophysica acta
Liver is the major organ that regulates whole body cholesterol metabolism. Disrupted hepatic cholesterol homeostasis contributes to the pathogenesis of nonalcoholic steatohepatitis, dyslipidemia, atherosclerosis, and cardiovascular diseases. Hepatic bile acid synthesis is the major catabolic mechanism for cholesterol elimination from the body. Furt...
Doonan, Lynley M. Fisher, Edward A. Brodsky, Jeffrey L.
Published in
Biochimica et biophysica acta
Understanding the molecular defects underlying cardiovascular disease is necessary for the development of therapeutics. The most common method to lower circulating lipids, which reduces the incidence of cardiovascular disease, is statins, but other drugs are now entering the clinic, some of which have been approved. Nevertheless, patients cannot to...
Andreev, Konstantin Martynowycz, Michael W. Huang, Mia L. Kuzmenko, Ivan Bu, Wei Kirshenbaum, Kent Gidalevitz, David
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Biochimica et biophysica acta
