Bottorf, Lauren Sahu, Indra D McCarrick, Robert M Lorigan, Gary A
Published in
Biochimica et biophysica acta. Biomembranes
Electron spin echo envelope modulation (ESEEM) spectroscopy in combination with site-directed spin labeling (SDSL) has been established as a valuable biophysical technique to provide site-specific local secondary structure of membrane proteins. This pulsed electron paramagnetic resonance (EPR) method can successfully distinguish between α-helices, ...
Stylianou, Andreas Gkretsi, Vasiliki Stylianopoulos, Triantafyllos
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Biochimica et biophysica acta. General subjects
Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types, including pancreatic tumors, the interplay between stromal cells and the other tumor microenvironment components leads to desmoplasia, a cancer-sp...
Senapati, Subhadip Gragg, Megan Samuels, Ivy S Parmar, Vipul M Maeda, Akiko Park, Paul S-H
Published in
Biochimica et biophysica acta. Biomembranes
Docosahexaenoic acid (DHA) is enriched in photoreceptor cell membranes. DHA deficiency impairs vision due to photoreceptor cell dysfunction, which is caused, at least in part, by reduced activity of rhodopsin, the light receptor that initiates phototransduction. It is unclear how the depletion of membrane DHA impacts the structural properties of rh...
Faccio, Andréa T Ruperez, Francisco J Singh, Nagendra S Angulo, Santiago Tavares, Marina F M Bernier, Michel Barbas, Coral Wainer, Irving W
Published in
Biochimica et biophysica acta. General subjects
Impairment in mitochondrial biogenesis and function plays a key role in depression and anxiety, both of which being associated with changes in fatty acid and phospholipid metabolism. The antidepressant effects of (R,S)-ketamine have been linked to its conversion into (2S,6S;2R,6R)-hydroxynorketamine (HNK); however, the connection between structure ...
Tang, Yan Gupta, Anuj Garimalla, Swetha Galinski, Mary R Styczynski, Mark P Fonseca, Luis L Voit, Eberhard O
Published in
Biochimica et biophysica acta. Molecular basis of disease
Disease represents a specific case of malfunctioning within a complex system. Whereas it is often feasible to observe and possibly treat the symptoms of a disease, it is much more challenging to identify and characterize its molecular root causes. Even in infectious diseases that are caused by a known parasite, it is often impossible to pinpoint ex...
Mishra, Om P Popov, Anatoliy V Pietrofesa, Ralph A Nakamaru-Ogiso, Eiko Andrake, Mark Christofidou-Solomidou, Melpo
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Biochimica et biophysica acta. General subjects
Myeloperoxidase (MPO) generates hypochlorous acid (HOCl) during inflammation and infection. We showed that secoisolariciresinol diglucoside (SDG) scavenges radiation-induced HOCl in physiological solutions. However, the action of SDG and its synthetic version, LGM2605, on MPO-catalyzed generation of HOCl is unknown. The present study evaluated the ...
Burstein, Suzanne R Kim, Hyun Jeong Fels, Jasmine A Qian, Liping Zhang, Sheng Zhou, Ping Starkov, Anatoly A Iadecola, Costantino Manfredi, Giovanni
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Biochimica et biophysica acta. Bioenergetics
Recent evidence highlights a role for sex and hormonal status in regulating cellular responses to ischemic brain injury and neurodegeneration. A key pathological event in ischemic brain injury is the opening of a mitochondrial permeability transition pore (MPT) induced by excitotoxic calcium levels, which can trigger irreversible damage to mitochon...
Patty, C H Lucas Luo, David A Snik, Frans Ariese, Freek Buma, Wybren Jan Ten Kate, Inge Loes van Spanning, Rob J M Sparks, William B Germer, Thomas A Garab, Győző
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Published in
Biochimica et biophysica acta. General subjects
Spectropolarimetry of intact plant leaves allows to probe the molecular architecture of vegetation photosynthesis in a non-invasive and non-destructive way and, as such, can offer a wealth of physiological information. In addition to the molecular signals due to the photosynthetic machinery, the cell structure and its arrangement within a leaf can ...
Wang, Wang Fernandez-Sanz, Celia Sheu, Shey-Shing
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Biochimica et biophysica acta. Molecular basis of disease
Recent advancement in mitochondrial research has significantly extended our knowledge on the role and regulation of mitochondria in health and disease. One important breakthrough is the delineation of how mitochondrial morphological changes, termed mitochondrial dynamics, are coupled to the bioenergetics and signaling functions of mitochondria. In ...
Naqvi, Afsar R Seal, Alexandra Shango, Jennifer Brambila, Maria F Martinez, Gloria Chapa, Gabriela Hasan, Shirin Yadavalli, Tejabhiram Jaishankar, Dinesh Shukla, Deepak
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Biochimica et biophysica acta. Gene regulatory mechanisms
MicroRNAs (miRNAs) are small, non-coding RNAs of ~18-25 nucleotides that have gained extensive attention as critical regulators in complex gene networks including immune cell lineage commitment, differentiation, maturation, and maintenance of immune homeostasis and function. Many viruses encode miRNAs that directly downregulate the expression of fa...
