Kuruba, Ramkumar Wu, Xin Reddy, Doodipala Samba
Published in
Biochimica et biophysica acta. Molecular basis of disease
Nerve agents and some pesticides such as diisopropylfluorophosphate (DFP) cause neurotoxic manifestations that include seizures and status epilepticus (SE), which are potentially lethal and carry long-term neurological morbidity. Current antidotes for organophosphate (OP) intoxication include atropine, 2-PAM and diazepam (a benzodiazepine for treat...
Sæle, Øystein Rød, Kari Elin L Quinlivan, Vanessa H Li, Shengrong Farber, Steven A
Published in
Biochimica et biophysica acta. Molecular and cell biology of lipids
The zebrafish larva is a powerful tool for the study of dietary triglyceride (TG) digestion and how fatty acids (FA) derived from dietary lipids are absorbed, metabolized and distributed to the body. While fluorescent FA analogues have enabled visualization of FA metabolism, methods for specifically assaying TG digestion are badly needed. Here we p...
Wu, Chao Li, Jianjun Tian, Chenchen Shi, Wen Jiang, Huimin Zhang, Zhen Wang, Hang Zhang, Quansheng Sun, Wei Sun, Peiqing
...
Published in
Biochimica et biophysica acta
T-cell acute lymphoblastic leukaemia (T-ALL) is a hematological malignancy caused by the accumulation of genomic lesions that affect the development of T-cells. ZEB1, a member of zinc finger-homeodomain family transcription factor, exhibits crucial function in promoting T-cell differentiation and potentially acts as a tumor suppressor in T-ALL. How...
Lou, Wenjia Reynolds, Christian A Li, Yiran Liu, Jenney Hüttemann, Maik Schlame, Michael Stevenson, David Strathdee, Douglas Greenberg, Miriam L
Published in
Biochimica et biophysica acta. Molecular and cell biology of lipids
Barth syndrome (BTHS) is an X-linked genetic disorder resulting from mutations in the tafazzin gene (TAZ), which encodes the transacylase that remodels the mitochondrial phospholipid cardiolipin (CL). While most BTHS patients exhibit pronounced skeletal myopathy, the mechanisms linking defective CL remodeling and skeletal myopathy have not been det...
Jahan, Rahat Macha, Muzafar A Rachagani, Satyanarayana Das, Srustidhar Smith, Lynette M Kaur, Sukhwinder Batra, Surinder K
Published in
Biochimica et biophysica acta
Alternative splicing is evolving as an eminent player of oncogenic signaling for tumor development and progression. Mucin 4 (MUC4), a type I membrane-bound mucin, is differentially expressed in pancreatic cancer (PC) and plays a critical role in its progression and metastasis. However, the molecular implications of MUC4 splice variants during disea...
Augstein, Antje Mierke, Johannes Poitz, David M Strasser, Ruth H
Published in
Biochimica et biophysica acta
Vascular smooth muscle cells (VSMC) exhibit a dual role in progression and maintenance of arteriosclerosis. They are fundamental for plaque stability but also can drive plaque progression. During pathogenic vascular remodeling, VSMC transdifferentiate into a phenotype with enhanced proliferation and migration. Moreover, they exert an increased capa...
M'baya-Moutoula, Eléonore Louvet, Loïc Molinié, Roland Guerrera, Ida Chiara Cerutti, Catherine Fourdinier, Ophélie Nourry, Virginie Gutierrez, Laurent Morlière, Patrice Mesnard, François
...
Published in
Biochimica et biophysica acta
Zhou, Jing Yu, Qing
Published in
Biochimica et biophysica acta. Molecular basis of disease
The levels of interleukin (IL)-7 and its receptor are elevated in the salivary glands of patients with Sjögren's syndrome (SS). Our previous study indicates that IL-7 plays a critical pathogenic role in the development and onset of SS in a mouse model of this disease. The present study aims at determining whether IL-7 also plays a role in sustainin...
Shin, Younghwa Moiseyev, Gennadiy Petrukhin, Konstantin Cioffi, Christopher L Muthuraman, Parthasarathy Takahashi, Yusuke Ma, Jian-Xing
Published in
Biochimica et biophysica acta. Molecular basis of disease
The retinoid visual cycle is an ocular retinoid metabolism specifically dedicated to support vertebrate vision. The visual cycle serves not only to generate light-sensitive visual chromophore 11-cis-retinal, but also to clear toxic byproducts of normal visual cycle (i.e. all-trans-retinal and its condensation products) from the retina, ensuring bot...
Agrawal, Anurag Weisshaar, James C
Published in
Biochimica et biophysica acta. Biomembranes
The outermost layer of Gram negative bacteria is composed of a lipopolysaccharide (LPS) network that forms a dense protective hydrophilic barrier against entry of hydrophobic drugs. At low μM concentrations, a large family of cationic polypeptides known as antimicrobial peptides (AMPs) are able to penetrate the LPS layer and permeabilize the outer ...
