Chen, Jiaxin Zhu, Haifeng Zhu, Yutao Zhao, Chenchen Wang, Shengyu Zheng, Yixin Xie, Ziang Jin, Yang Song, Honghai Yang, Linjun
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Published in
Bioactive materials
Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism of extracellular matrix, and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc (IVD) degeneration. Herein, we constructed a siSTING delivery hydroge...
Huang, Hao Yuan, Guotao Xu, Ying Gao, Yuan Mao, Qiulian Zhang, Yin Bai, Lu Li, Weijie Wu, Anqing Hu, Wentao
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Published in
Bioactive materials
The integration of photothermal therapy (PTT) with gene therapy (GT) in a single nanoscale platform demonstrates great potential in cancer therapy. Porous iron oxide nanoagents (PIONs) are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal therapy. However, the therapeutic effic...
Kou, Longfa Jiang, Xinyu Tang, Yingying Xia, Xing Li, Yingtao Cai, Aimin Zheng, Hailun Zhang, Hailin Ganapathy, Vadivel Yao, Qing
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Bioactive materials
Reprogramed cellular metabolism is one of the most significant hallmarks of cancer. All cancer cells exhibit increased demand for specific amino acids, and become dependent on either an exogenous supply or upregulated de novo synthesis. The resultant enhanced availability of amino acids supports the reprogramed metabolic pathways and fuels the mali...
Zhou, Yuhan Ye, Ting Ye, Chengzhi Wan, Chao Yuan, Siyue Liu, Yushuai Li, Tianyu Jiang, Fagang Lovell, Jonathan F Jin, Honglin
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Bioactive materials
Autologous tumor cells and cell-derived secretions (CDS) can induce antitumor immune responses. The conditions in which cells are cultured and treated impact CDS, and cellular insults alter their composition and function. In this study, we generated CDS from tumor cells exposed to normal culture conditions, hypoxia, cisplatin, radiotherapy, photody...
Wang, Li Guo, Xiaolei Chen, Jiaqing Zhen, Zhen Cao, Bin Wan, Wenqian Dou, Yuandong Pan, Haobo Xu, Feng Zhang, Zepu
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Bioactive materials
With the interdisciplinary convergence of biology, medicine and materials science, both research and clinical translation of biomaterials are progressing at a rapid pace. However, there is still a huge gap between applied basic research on biomaterials and their translational products - medical devices, where two significantly different perspective...
Martins, João P Figueiredo, Patrícia Wang, Shiqi Espo, Erika Celi, Elena Martins, Beatriz Kemell, Marianna Moslova, Karina Mäkilä, Ermei Salonen, Jarno
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Bioactive materials
Oral insulin delivery could change the life of millions of diabetic patients as an effective, safe, easy-to-use, and affordable alternative to insulin injections, known by an inherently thwarted patient compliance. Here, we designed a multistage nanoparticle (NP) system capable of circumventing the biological barriers that lead to poor drug absorpt...
Li, Yang Fu, Rongzhan Duan, Zhiguang Zhu, Chenhui Fan, Daidi
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Bioactive materials
Bacterial infection, tissue hypoxia and inflammatory response can hinder the infected wound repair process. To mitigate the above issues, tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets ([email protected]/Fe NSs) with dual enzyme activities were developed and anchored to a multifunctional hydrogel. The hydrogel exhibited excellent antibacte...
Zhong, Jiamin Wang, Hao Yang, Ke Wang, Huifeng Duan, Chongwen Ni, Na An, Liqin Luo, Yetao Zhao, Piao Gou, Yannian
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Published in
Bioactive materials
Skin injury is repaired through a multi-phase wound healing process of tissue granulation and re-epithelialization. Any failure in the healing process may lead to chronic non-healing wounds or abnormal scar formation. Although significant progress has been made in developing novel scaffolds and/or cell-based therapeutic strategies to promote wound ...
Zhan, Jie Wang, Yuhan Ma, Shaodan Qin, Qin Wang, Ling Cai, Yanbin Yang, Zhimou
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Bioactive materials
Organelles are responsible for the efficient storage and transport of substances in living systems. A myriad of extracellular vesicles (EVs) acts as a bridge to exchange signaling molecules in cell-cell communication, and the highly dynamic tubulins and actins contribute to efficient intracellular substance transport. The inexhaustible cues of natu...
Choi, Hyunsik Jeong, Sang Hoon Kim, Tae Yeon Yi, Jeeyoon Hahn, Sei Kwang
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Bioactive materials
Self-propelling micro- and nano-motors (MNMs) have been extensively investigated as an emerging oral drug delivery carrier for gastrointestinal (GI) tract diseases. However, the propulsion of current MNMs reported so far is mostly based on the redox reaction of metals (such as Zn and Mg) with severe propulsion gas generation, remaining non-degradab...
