Richter, O Betz, A Giersch, C
Published in
Bio Systems
The glycolytic pathway is described by a set of coupled non linear differential equations of first order with respect to time. The individual terms of these equations consist of enzyme velocities assuming a steady state hypothesis for the enzymatic forms. These are specified and the system is solved numerically. Oscillations are explained by intera...
Alberghina, F A
Published in
Bio Systems
The assumption that prompted the studies reported in this paper was that the unsatisfactory state of our knowledge on the regulation of cellular growth might derive from the reductionistic approach used to investigate it. Thus an analysis of cellular growth which applied concepts derived from systems dynamics was undertaken. First of all a dynamic ...
Tóth-Martinez, B L Papp, S Dinya, Z Hernádi, F J
Published in
Bio Systems
Boeynaems, J M Swillens, S Dumont, J E
Published in
Bio Systems
An original model of hormone-receptor interaction is proposed: the hormone would interact with its receptor by dissociating a regulatory unit from a catalytic unit, which, freed from the negative constraint exerted by the regulatory unit, would become active. It is shown that such a model shares some features with negatively cooperative models: 1. ...
Ivatt, R J
Published in
Bio Systems
A technique is described for assaying membrane bound enzymes. The results of studies with two sequential glycoprotein:glycosyl transferases are presented. The results are discussed in the light of recent suggestions concerning the structural organisation of these enzymes. A description, of the specificity of these enzymes for high molecular weight ...
Schwartz, A W
Published in
Bio Systems
Gánti, T
Published in
Bio Systems
Fox, S W
Published in
Bio Systems
Rapoport, T A Heinrich, R
Published in
Bio Systems
A mathematical model for the glycolysis of human erythrocytes is presented which takes into account ATP-synthesis and -consumption. A set of three differential equations describes the steady states and the time-dependent changes of the metabolite concentrations under blood storage conditions. For a given parameter combination there are in general t...
Wagner, E Deitzer, G F Fischer, S Frosh, S Kempf, O Stroebele, L
Published in
Bio Systems
Evidence is presented for endogenous rhythmicity in energy transducing sequences of cellular metabolism which result in a circadian rhythm in adenylate "energy charge" and redox state (NADPH/NADP). From phase dependent photocontrol of enzymatic activity and pyridine nucleotide pool-size levels it is concluded that light - via photoreceptor(s) of ph...
