Sakai, Hiroyasu Misawa, Miwa
Published in
Basic & clinical pharmacology & toxicology
Sodium azulene sulfonate is a water-soluble derivative of azulene which is an antiinflammatory component of chamomile of the family of Asteraceae. Sodium azulene sulfonate is clinically used as a therapeutic agent in the treatment of pharyngitis as well as other inflammatory diseases such as tonsillitis, stomatitis and conjunctivitis. There has bee...
Woodburn, Kathryn W Wilson, Susan D Fong, Kei-Lai Schatz, Peter J Spainhour, Charles B Norton, Daniel
Published in
Basic & Clinical Pharmacology & Toxicology
Hematide™ is a synthetic peptide-based, PEGylated erythropoiesis-stimulating agent, which is being developed for the chronic treatment of anaemia associated with chronic renal failure. To support the safety of long-term dosing of chronic renal failure patients, a comprehensive toxicology programme was implemented including rat subchronic and chroni...
Kanaan, Mouna Daali, Youssef Dayer, Pierre Desmeules, Jules
Published in
Basic & Clinical Pharmacology & Toxicology
Abstract: The analgesic effect of tramadol (TMD) results from the monoaminergic effect of its two enantiomers, (+)-TMD and (−)-TMD as well as its opioid metabolite (+)- O -desmethyl-tramadol (M1). P -glycoprotein ( P -gp) might be of importance in the analgesic and tolerability profile variability of TMD. Our study investigated the involvement of P...
Larsen, Søren T Roursgaard, Martin Jensen, Keld A Nielsen, Gunnar D
Published in
Basic & clinical pharmacology & toxicology
The purpose of this study was to investigate whether photocatalytic TiO(2) nanoparticles have adjuvant effect, when administered in combination with ovalbumin (OVA) in mice. Mice were immunized via intraperitoneal injections of OVA, OVA + TiO(2) or OVA + Al(OH)(3) and challenged with aerosols of OVA. At the end of the study, serum was analysed for ...
Raghunath, Azhwar Nagarajan, Raju Sundarraj, Kiruthika Palanisamy, Kavipriya Perumal, Ekambaram
Published in
Basic & Clinical Pharmacology & Toxicology
The Keap1-Nrf2-ARE system serves as a premier defence mechanism to curb oxidative stress, which remains as one of the major causes of ageing and pathogenesis in various diseases. Nrf2 is the principal master regulator of the cellular defence system, and its activation remains the prospective therapeutic approach against chronic diseases. One of the...
Saeedi‐Boroujeni, Ali Mahmoudian‐Sani, Mohammad‐Reza Mohammad Bahadoram Alghasi, Arash
Published in
Basic & Clinical Pharmacology & Toxicology
Pandolfi, Sergio Chirumbolo, Salvatore
Published in
Basic & Clinical Pharmacology & Toxicology