Hugosdottir, Rosa Mørch, Carsten Dahl Jørgensen, Cecilia Klitgaard Nielsen, Camilla Winther Olsen, Mathias Vassard Pedersen, Mads Jozwiak Tigerholm, Jenny
Published in
BMC Neuroscience
BackgroundThere is a need for new approaches to increase the knowledge of the membrane excitability of small nerve fibers both in healthy subjects, as well as during pathological conditions. Our research group has previously developed the perception threshold tracking technique to indirectly assess the membrane properties of peripheral small nerve ...
Narayan, Daniel S. Ao, Jack Wood, John P. M. Casson, Robert J. Chidlow, Glyn
Published in
BMC Neuroscience
BackgroundThe Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we performed a systematic characterization of the spatio-temporal patterns of S- and M/L-opsin+ cone outer segment ...
Shin, Seung Han Kim, Ee-Kyung Lee, Kyung-yup Kim, Han-Suk
Published in
BMC Neuroscience
BackgroundSystemic inflammation is an important risk factor for neurodevelopmental impairments in preterm infants. Premyelinating oligodendrocytes are main building blocks of white matter in preterm infants and vulnerable to oxidative stress and excitotoxic stress. Tumour necrosis factor-α (TNF-α) plays important roles in systemic inflammation and ...
Ratliff, Whitney A. Saykally, Jessica N. Mervis, Ronald F. Lin, Xiaoyang Cao, Chuanhai Citron, Bruce A.
Published in
BMC Neuroscience
BackgroundTraumatic brain injury (TBI) is a widespread public health problem and a signature injury of our military in modern conflicts. Despite the long-term effects of even mild brain injuries, an effective treatment remains elusive. Coffee and several of its compounds, including caffeine, have been identified as having neuroprotective effects in...
Huang, Jue Ulke, Christine Strauss, Maria
Published in
BMC Neuroscience
BackgroundThe aim of the present study was to evaluate the stability of brain arousal in adult attention-deficit/hyperactivity disorder (ADHD) outpatients with and without depressive symptomatology, and its association with depressive symptom severity and absolute electroencephalogram (EEG) power in different frequency bands.MethodsWe included 31 o...
Huang, Lixuan Ren, Yande Zeng, Zisan Ren, Hao Li, Shaojun He, Shengnan He, Fan Li, Xiangrong
Published in
BMC Neuroscience
BackgroundParkinson's disease is a progressive degenerative nervous system disease. Recent studies have shown that secondary changes in the GABA system play directly affect the pathogenesis of PD. There is still much debate about GABA concentrations because currently, GABA concentrations in the brain tissue are obtained indirectly by measuring its ...
Zhu, Xiaobo Liu, Jiankun Chen, Shaojie Xue, Jiang Huang, Shanying Wang, Yibiao Chen, Ou
Published in
BMC Neuroscience
BackgroundOxidative stress and neuroinflammation are central pathogenic mechanisms common to many neurological diseases. Isoliquiritigenin (ISL) is a flavonoid in licorice with multiple pharmacological properties, including anti-inflammatory activity, and has demonstrated protective efficacy against acute neural injury. However, potential actions a...
Zhang, Keying Guo, Ling Zhang, Junping An, Guangzhou Zhou, Yan Lin, Jiajin Xing, Junling Lu, Mai Ding, Guirong
Published in
BMC Neuroscience
BackgroundTranscranial direct current stimulation (tDCS) is a noninvasive neural control technology that has become a research hotspot. To facilitate further research of tDCS, the biosafety of 500 μA cathodal tDCS, a controversial parameter in rats was evaluated.Results24 animals were randomly divided into two groups: a cathodal tDCS group (tDCS, n...
Liang, Minglong Xiao, He Xie, Bing Yin, Xuntao Wang, Jian Yang, Hong
Published in
BMC Neuroscience
BackgroundAmblyopia is generally considered a neurodevelopmental disorder that results from abnormal visual experiences in early childhood and may persist to adulthood. The neural basis of amblyopia has been a matter of interest for many decades, but the critical neural processing sites in amblyopia are not entirely understood. Although many functi...
Xu, Bing Mo, Cheng Lv, Chengmei Liu, Susu Li, Jun Chen, Jieying Wei, Yanhong An, Hongwei Ma, Li Guan, Xuehai
...
Published in
BMC Neuroscience
BackgroundPostoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase (PI3K) has been reported to have an important role in neuropathic and inflammatory pain. Our previous research revealed that pre-su...
