Chen, Luxi Barnett, Rosemary E. Horstmann, Martin Bamberger, Verena Heberle, Lea Krebs, Nina Colbourne, John K. Gómez, Rocío Weiss, Linda C.
Published in
BMC Cell Biology
BackgroundDiapause is a form of dormancy that is genetically predetermined to allow animals to overcome harsh environmental conditions. It is induced by predictive environmental cues bringing cellular activity levels into a state of suspended animation. Entering diapause requires organismal, molecular and cellular adaptation to severely reduced ene...
Guo, Zhi Lan Li, Jing Zhe Ma, Yan Yan Qian, Dan Zhong, Ju Ying Jin, Meng Meng Huang, Peng Che, Lu Yang Pan, Bing Wang, Yi
...
Published in
BMC Cell Biology
BackgroundTRAIL, tumor necrosis factor-related apoptosis-inducing ligand, can selectively kill cancer cells with little or no cytotoxicity toward normal human cells and is regarded as a potential relatively safe antitumor drug. However, some cancer cells are resistant to TRAIL-induced apoptosis. Thus, reagents that potentiate TRAIL-induced cytotoxi...
Skoko, Josip Rožanc, Jan Charles, Emilie M. Alexopoulos, Leonidas G. Rehm, Markus
Published in
BMC Cell Biology
BackgroundDasatinib (Sprycel) was developed as a tyrosine kinase inhibitor targeting Bcr-Abl and the family of Src kinases. Dasatinib is commonly used for the treatment of acute lymphoblastic and chronic myelogenous leukemia. Previous clinical studies in melanoma returned inconclusive results and suggested that patients respond highly heterogeneous...
Mu, Yongxu Wu, Xiaoyun Hao, Zhiming
Published in
BMC Cell Biology
BackgroundWithin the past years, umbilical cord (UC) and amniotic membrane (AM) expanded in human platelet lysate (PL) have been found to become increasingly candidate of mesenchymal stromal cells (MSCs) in preclinical and clinical studies. Different sources of MSCs have different properties, and lead to different therapeutic applications. However,...
Suryavanshi, Narendra Furmston, Joanna Ridley, Anne J.
Published in
BMC Cell Biology
BackgroundEndothelial cells provide a barrier between blood and tissues, which is regulated to allow molecules and cells in out of tissues. Patients with cerebral cavernous malformations (CCM) have dilated leaky blood vessels, especially in the central nervous system. A subset of these patients has loss-of-function mutations in CCM3. CCM3 is part o...
Babic, Julien Griscom, Laurent Cramer, Jeremy Coudreuse, Damien
Published in
BMC Cell Biology
BackgroundReal-time monitoring of cellular responses to dynamic changes in their environment or to specific treatments has become central to cell biology. However, when coupled to live-cell imaging, such strategies are difficult to implement with precision and high time resolution, and the simultaneous alteration of multiple parameters is a major c...
Lewis, Tylor R. Kundinger, Sean R. Link, Brian A. Insinna, Christine Besharse, Joseph C.
Published in
BMC Cell Biology
BackgroundKIF17, a kinesin-2 motor that functions in intraflagellar transport, can regulate the onset of photoreceptor outer segment development. However, the function of KIF17 in a mature photoreceptor remains unclear. Additionally, the ciliary localization of KIF17 is regulated by a C-terminal consensus sequence (KRKK) that is immediately adjacen...
Xie, Bo Liu, Xinyu Yang, Jie Cheng, Jinke Gu, Jianmin Xue, Song
Published in
BMC Cell Biology
BackgroundMyocardial ischemia-reperfusion injury (IRI) has become one of the most serious complications after reperfusion therapy in patients with acute myocardial infarction. Small ubiquitin-like modification (SUMOylation) is a reversible process, including SUMO E1-, E2-, and E3-mediated SUMOylation and SUMO-specific protease-mediated deSUMOylatio...
Zhu, Honghua Liu, Wei Fang, Hao
Published in
BMC Cell Biology
BackgroundDisruption to the blood brain barrier (BBB) is a leading factor associated with the development of postoperative cognitive dysfunction (POCD). Despite this, the underlying mechanism by which BBB disruption promotes POCD in the elderly population has not yet been not fully elucidated.ResultsIn this study, we established a POCD mice model u...
Alaei, Sarah R. Abrams, Charles K. Bulinski, J. Chloë Hertzberg, Elliot L. Freidin, Mona M.
Published in
BMC Cell Biology
BackgroundThe gap junction protein, Connexin32 (Cx32), is expressed in various tissues including liver, exocrine pancreas, gastrointestinal epithelium, and the glia of the central and peripheral nervous system. Gap junction-mediated cell-cell communication and channel-independent processes of Cx32 contribute to the regulation of physiological and c...