Chibaudel, Benoist Bonnetain, Franck Tournigand, Christophe de Larauze, Marine Hug de Gramont, Armand Laurent-Puig, Pierre Paget, Jérôme Hadengue, Alexandra Notelet, Dominique Benetkiewicz, Magdalena
...
Published in
BMC Cancer
BackgroundThe management of unresectable metastatic colorectal cancer (mCRC) is a comprehensive treatment strategy involving several lines of therapy, maintenance, salvage surgery, and treatment-free intervals. Besides chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan), molecular-targeted agents such as anti-angiogenic agents (bevacizumab, af...
Tan, Dong-Feng Huberman, Joel A Hyland, Andrew Loewen, Gregory M Brooks, John SJ Beck, Amy F Todorov, Ivan T Bepler, Gerold
Published in
BMC Cancer
BackgroundBecause cells progressing to cancer must proliferate, marker proteins specific to proliferating cells may permit detection of premalignant lesions. Here we compared the sensitivities of a classic proliferation marker, Ki-67, with a new proliferation marker, MCM2, in 41 bronchial biopsy specimens representing normal mucosa, metaplasia, dys...
Pornthanakasem, Wichai Shotelersuk, Kanjana Termrungruanglert, Wichai Voravud, Narin Niruthisard, Somchai Mutirangura, Apiwat
Published in
BMC Cancer
BackgroundHuman papillomavirus (HPV) is a crucial etiological factor for cervical cancer (CC) development. From a diagnostic view-point, the consistent presence of HPV in CC allows the viral DNA to be used as a genetic marker. The aims of this study were to evaluate the presence, physical status and clinical significant of HPV DNA in circulation of...
Kongruttanachok, Narisorn Sukdikul, Sairoong Setavarin, Surachai Kerekhjanarong, Verachai Supiyaphun, Pakpoom Voravud, Narin Poovorawan, Yong Mutirangura, Apiwat
Published in
BMC Cancer
BackgroundNasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is responsible for the metabolic activation of nitrosamines, and has been shown to be a susceptibility gene for NPC development in Taiwan [RR = 2.6; 95%C...
Heise, Joachim W Heep, Hansjörg Frieling, Thomas Sarbia, Mario Hartmann, Karl A Röher, Hans-Dietrich
Published in
BMC Cancer
BackgroundThe effectiveness of neoadjuvant treatment (NT) prior to resection of squamous cell carcinoma of the esophagus (SCCE) in terms of prolonged survival has not been proven by randomized trials. Facing considerable financial expenses and with concerns regarding the consumption of the patient's remaining survival time, this study aims to provi...
Limtrakul, Porn-ngarm Anuchapreeda, Songyot Lipigorngoson, Suwiwek Dunn, Floyd W
Published in
BMC Cancer
BackgroundWe investigated the chemopreventive action of dietary curcumin on 7,12-dimethylbenz(a)anthracene (DMBA)-initiated and 12,0-tetradecanoylphorbol-13-acetate (TPA)-promoted skin tumor formation in Swiss albino mice. Curcumin, a yellow coloring matter isolated from roots of Curcuma longa Linn, is a phenolic compound possessing antioxidant, fr...
Kuranaga, Noritsugu Shinomiya, Nariyoshi Mochizuki, Hidetaka
Published in
BMC Cancer
BackgroundThe role of telomerase activation in the expression and/or maintenance of drug resistance is not clearly understood. Therefore, we investigated the relationships, among the telomerase activity, telomere length and the expression of multidrug resistance genes in colorectal cancer cell lines cultivated with anti-cancer drugs.MethodsLoVo and...
Merrill, Ray M Lyon, Joseph L Wiggins, Charles
Published in
BMC Cancer
BackgroundTwo methods are presented for obtaining hysterectomy prevalence corrected estimates of invasive cancer incidence rates and probabilities of the corpus uterine.MethodsThe first method involves cross-sectional hysterectomy data from the Utah Hospital Discharge Data Base and mortality data applied to life-table methods. The second involves h...
Nakaji, Shigeyuki Shimoyama, Tadashi Umeda, Takashi Sakamoto, Juichi Katsura, Shuji Sugawara, Kazuo Baxter, David
Published in
BMC Cancer
BackgroundSince Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan.MethodsA multiple regression analysis (using t...
Mastronardi, Luciano Guiducci, Antonio Puzzilli, Fabrizio
Published in
BMC Cancer
Aims and backgroundThe Ki-67 is a nuclear antigen detected by the monoclonal antibody MIB-1 and its Labeling Index (LI) is considered a marker of normal and abnormal cell proliferation. Pituitary adenomas are generally well differentiated neoplasms, even if in about one third of cases they are invasive of surrounding tissues. The aim of this study ...
