Chibaudel, Benoist Bonnetain, Franck Tournigand, Christophe de Larauze, Marine Hug de Gramont, Armand Laurent-Puig, Pierre Paget, Jérôme Hadengue, Alexandra Notelet, Dominique Benetkiewicz, Magdalena
...
Published in
BMC Cancer
BackgroundThe management of unresectable metastatic colorectal cancer (mCRC) is a comprehensive treatment strategy involving several lines of therapy, maintenance, salvage surgery, and treatment-free intervals. Besides chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan), molecular-targeted agents such as anti-angiogenic agents (bevacizumab, af...
Limtrakul, Porn-ngarm Anuchapreeda, Songyot Lipigorngoson, Suwiwek Dunn, Floyd W
Published in
BMC Cancer
BackgroundWe investigated the chemopreventive action of dietary curcumin on 7,12-dimethylbenz(a)anthracene (DMBA)-initiated and 12,0-tetradecanoylphorbol-13-acetate (TPA)-promoted skin tumor formation in Swiss albino mice. Curcumin, a yellow coloring matter isolated from roots of Curcuma longa Linn, is a phenolic compound possessing antioxidant, fr...
Pornthanakasem, Wichai Shotelersuk, Kanjana Termrungruanglert, Wichai Voravud, Narin Niruthisard, Somchai Mutirangura, Apiwat
Published in
BMC Cancer
BackgroundHuman papillomavirus (HPV) is a crucial etiological factor for cervical cancer (CC) development. From a diagnostic view-point, the consistent presence of HPV in CC allows the viral DNA to be used as a genetic marker. The aims of this study were to evaluate the presence, physical status and clinical significant of HPV DNA in circulation of...
Tomita, Masaki Ayabe, Takanori Matsuzaki, Yasunori Edagawa, Masao Maeda, Masayuki Shimizu, Tetsuya Hara, Masaki Onitsuka, Toshio
Published in
BMC Cancer
BackgroundWe assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma.MethodsFormalin-fixed and paraffin-embedded tissue sections from 45 patients who were treated surgically were used in this study. Pathologists graded lymphatic and blood vessel i...
Kongruttanachok, Narisorn Sukdikul, Sairoong Setavarin, Surachai Kerekhjanarong, Verachai Supiyaphun, Pakpoom Voravud, Narin Poovorawan, Yong Mutirangura, Apiwat
Published in
BMC Cancer
BackgroundNasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is responsible for the metabolic activation of nitrosamines, and has been shown to be a susceptibility gene for NPC development in Taiwan [RR = 2.6; 95%C...
Meert, Anne-Pascale Paesmans, Marianne Berghmans, Thierry Martin, Benoît Mascaux, Céline Vallot, Frédéric Verdebout, Jean-Marc Lafitte, Jean-Jacques Sculier, Jean-Paul
Published in
BMC Cancer
PurposeA systematic review of the literature was carried out to determine the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) .MethodsTo be eligible, full published trials needed to deal with SCLC and to have randomly assigned patients to receive PCI or not. Trials quality was assessed by two scores (Chalmers and ELC...
Tan, Dong-Feng Huberman, Joel A Hyland, Andrew Loewen, Gregory M Brooks, John SJ Beck, Amy F Todorov, Ivan T Bepler, Gerold
Published in
BMC Cancer
BackgroundBecause cells progressing to cancer must proliferate, marker proteins specific to proliferating cells may permit detection of premalignant lesions. Here we compared the sensitivities of a classic proliferation marker, Ki-67, with a new proliferation marker, MCM2, in 41 bronchial biopsy specimens representing normal mucosa, metaplasia, dys...
Nagtegaal, Iris D Marijnen, Corrie AM Kranenbarg, Elma Klein Mulder-Stapel, Adri Hermans, Jo van de Velde, Cornelis JH van Krieken, J Han JM
Published in
BMC Cancer
BackgroundInvasion and metastasis is a complex process governed by the interaction of genetically altered tumor cells and the immunological and inflammatory host reponse. Specific T-cells directed against tumor cells and the nonspecific inflammatory reaction due to tissue damage, cooperate against invasive tumor cells in order to prevent recurrence...
Høyer, Annette P Jørgensen, Torben Rank, Fritz Grandjean, Philippe
Published in
BMC Cancer
BackgroundThe relationship between breast cancer and organochlorine exposure is controversial and complex. As estrogen receptor positive and negative breast cancer may represent different entities of the disease, this study was undertaken to evaluate organochlorines influence on breast cancer risk and survival according to receptor status.MethodsTh...
Graziano, Francesco Cascinu, Stefano Staccioli, Maria Pia Catalano, Vincenzo Rossi, Maria Cristina Baldelli, Anna Maria Giordani, Paolo Muretto, Pietro Catalano, Giuseppina
Published in
BMC Cancer
BackgroundLoss of activity of tumor suppressor genes is considered a fundamental step in a genetic model of carcinogenesis. Altered expression of the p53 and the Deleted in Colon Cancer (DCC) proteins has been described in gastric cancer and this event may have a role in the development of the disease. According to this hypothesis, we investigated ...
