Correction to: Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physica...
Published in BMC Cancer
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Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer
Published in BMC Cancer
BackgroundBreast cancer is the leading cause of cancer related death in women, with metastasis the principle cause of mortality. New non-invasive prognostic markers are needed for the early detection of metastasis, facilitating treatment decision optimisation. MicroRNA (miRNA) are small, non-coding RNAs regulating gene expression and involved in ma...
Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disabilit...
Published in BMC Cancer
BackgroundSeveral subunits of the SWI/SNF chromatin remodeling complex are implicated in both cancer and neurodevelopmental disorders (NDD). Though there is no clinical evidence for an increased tumor risk in individuals with NDDs due to germline mutations in most of these genes so far, this has been repeatedly proposed and discussed. A young woman...
Downstaging in opportunistic breast cancer screening in Brazil: a temporal trend analysis
Published in BMC Cancer
BackgroundBreast cancer is the most common female cancer in Brazil with an estimated 60 thousand new cases per year. Widespread use of mammography opportunistic screening has been observed in the last 20 years, including women under 50 years old. The present study aimed to analyse the trends in breast cancer stage distribution at diagnosis as a fun...
AVAiLABLE NIS – AVASTIN® in lung cancer treatment in routine oncology practice in Germany
Published in BMC Cancer
BackgroundBevacizumab (Avastin®), a recombinant humanized monoclonal antibody, in combination with platinum-doublet chemotherapy has become a routine treatment for advanced non-small-cell lung cancer (NSCLC). The post-authorization, non-interventional study ‘AVAiLABLE’ assessed the effectiveness and safety of bevacizumab combined with chemotherapy ...
Correction to: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metast...
Published in BMC Cancer
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Tissue-specific impact of stem-loops and quadruplexes on cancer breakpoints formation
Published in BMC Cancer
BackgroundChromosomal rearrangements are the typical phenomena in cancer genomes causing gene disruptions and fusions, corruption of regulatory elements, damage to chromosome integrity. Among the factors contributing to genomic instability are non-B DNA structures with stem-loops and quadruplexes being the most prevalent. We aimed at investigating ...
Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful v...
...Published in BMC Cancer
BackgroundThe spine is the most frequent location of bone metastases. Local treatment aims at palliation of pain and, given the increased likelihood of long-term cancer survival, at local control. Kyphoplasty and intraoperative radiotherapy (Kypho-IORT) provided instantaneous pain relief in 70% of patients at the first day after the intervention an...
Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generati...
Published in BMC Cancer
BackgroundColorectal cancer remains the second leading cause of cancer death in the United States, and increased risk in patients with ulcerative colitis (a subset of inflammatory bowel disease) has motivated studies into early markers of dysplasia. The development of clinically translatable multiphoton imaging systems has allowed for the potential...
Prognostic impact of tumor location in colon cancer: the Monitoring of Cancer Incidence in Japan (MCIJ) project
Published in BMC Cancer
BackgroundColorectal cancer (CRC) is globally one of the most common cancers. Although studies have found a significant prognostic impact of cancer location for right-sided colon cancers compared with those of the left-side, evidence is lacking in a Japanese population. Therefore, we investigated 5-year net survival in colon cancer by tumor site in...
