Miwa, Keisuke Oki, Eiji Enomoto, Masanobu Ihara, Keisuke Ando, Koji Fujita, Fumihiko Tominaga, Masahiro Mori, Shinichiro Nakayama, Goro Shimokawa, Mototsugu
...
Published in
BMC Cancer
BackgroundPreoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadjuvant chemotherapy (NAC) regimen...
James, G. D. Symeonides, S. Marshall, J. Young, J. Clack, G.
Published in
BMC Cancer
BackgroundThe continual reassessment method (CRM) identifies the maximum tolerated dose (MTD) more efficiently and identifies the true MTD more frequently compared to standard methods such as the 3 + 3 method. An initial estimate of the dose-toxicity relationship (prior skeleton) is required, and there is limited guidance on how to select this. Pre...
Tao, Shuangfen Gu, Jianchun Wang, Qing Zheng, Leizhen
Published in
BMC Cancer
BackgroundAnti-apoptotic protein Bcl-2 plays a substantial role in the carcinogenesis, whereas the regulation for Bcl-2 in gastric carcinoma (GC) is poorly understood. Specifically, a role of microRNA (miR)-383 in the control of Bcl-2 has not been shown in GC and thus addressed in the current study.MethodsWe investigated the levels of miR-383 and B...
Vecchiato, Antonella Mocellin, Simone Del Fiore, Paolo Tosti, Giulio Ascierto, Paolo A. Corradin, Maria Teresa De Giorgi, Vincenzo Giudice, Giuseppe Queirolo, Paola Ferreli, Caterina
...
Published in
BMC Cancer
BackgroundReproducible, high-quality surgery is a key point in the management of cancer patients. Quality indicators for surgical treatment of melanoma has been presented with benchmarks but data on morbidity are still limited. This study presents the quality indicators on morbidity after surgical treatment for non-metastatic skin melanoma in an It...
Chen, Xi Wu, Hongjin Feng, Jia Li, Ying Lv, Jiao Shi, Weikai Fan, Weiwei Xiao, Li Sun, Danmeng Jiang, Mingfeng
...
Published in
BMC Cancer
BackgroundThe growth- and plasticity-associated protein-43 (GAP43) is biasedly expressed in indigestive system and nervous system. Recent study has shown that GAP43 is responsible for the development of neuronal growth and axonal regeneration in normal nervous tissue, while serves as a specific biomarker of relapsed or refractory neuroblastoma. How...
Lim, Jihye Kim, Ha Il Kim, Eunju Kim, Jiyoon An, Jihyun Chang, Seheon Kim, Seon-Ok Lee, Han chu Lee, Yung Sang Shim, Ju Hyun
...
Published in
BMC Cancer
BackgroundWe hypothesized that portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) increases portal pressure and causes esophageal varices and variceal bleedings. We examined the incidence of high-risk varices and variceal bleeding and determined the indications for variceal screening and prophylaxis.MethodsThis study included 170...
Toor, Kabirraaj Middleton, Mark R. Chan, Keith Amadi, Adenike Moshyk, Andriy Kotapati, Srividya
Published in
BMC Cancer
BackgroundImmune checkpoint inhibitors and targeted therapies are approved for adjuvant treatment of patients with resected melanoma; however, they have not been compared in randomized controlled trials (RCTs). We compared the efficacy and safety of adjuvant nivolumab with other approved treatments using available evidence from RCTs in a Bayesian n...
Wang, Xinxin Li, Shuo Sun, Yihong Li, Kai Shen, Xian Xue, Yingwei Liang, Pin Li, Guoli Chen, Luchuan Zhao, Qun
...
Published in
BMC Cancer
BackgroundCuring locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with gastric cancer based on several clinical trials. According to phase II studies and guidelines, SOX regimen as neoadjuvant chemotherapy is efficient. However, the optimal duration o...
Gheerbrant, Hubert Timsit, Jean-François Terzi, Nicolas Ruckly, Stéphane Laramas, Mathieu Levra, Matteo Giaj Jacquet, Emmanuelle Falque, Loic Moro-Sibilot, Denis Toffart, Anne-Claire
...
Published in
BMC Cancer
BackgroundAt intensive care unit (ICU) admission, the issue about prognosis of critically ill cancer patients is of clinical interest, especially after ICU discharge. Our objective was to assess the factors associated with 3- and 6-month survival of ICU cancer survivors.MethodsBased on the French OutcomeRea™ database, we included solid cancer patie...
Martín-Aguilar, Ana Elena Núñez-López, Haidé Ramirez-Sandoval, Juan C.
Published in
BMC Cancer
BackgroundSequential inhibition of the vascular endothelial growth factor (VEGF) pathway with sorafenib could be useful for patients with metastatic renal cell carcinoma (RCC). Our aim was to determine the activity and tolerability of sorafenib as a second-line therapy in advanced RCC initially treated with a different VEGF-tyrosine kinase inhibito...
