Published in Asia-Pacific journal of clinical oncology
Abstract The use of immunotherapeutics in melanoma has received much attention, and recent advances to further characterize the regulatory components of the immune system and the importance of co-stimulatory molecules have opened a new area for clinical investigation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) serves as a negative regulat...
Published in Asia-Pacific journal of clinical oncology
High tumor grade and advanced stage were significantly predictive of poor survival outcome in patients with primary appendiceal carcinomas.
Published in Asia-Pacific journal of clinical oncology
The benefit of PLD in platinum-resistant recurrent ovarian cancer is small and the treatment has considerable toxicity. These data support the need to establish whether chemotherapy in this setting has any favorable effect on quality of life. The Australian New Zealand Gynaecological Oncology Group is currently addressing this question in a large p...
Published in Asia-Pacific journal of clinical oncology
A number of studies have shown that melanoma is a particularly immunogenic tumour, at least in the early stages of its development. A range of clinical phenomena also suggests that immune responses play an important role in the natural history of the disease, including the total or partial regression of primary melanomas associated with lymphoid in...
Published in Asia-Pacific journal of clinical oncology
Late presentation with advanced disease, poor nutritional status and high risk of exposure to infective agents all contribute to the high mortality in patients treated with intensive protocols in resource-poor countries.
Published in Asia-Pacific journal of clinical oncology
This study showed that factors such as primary clinical signs, stage of primary tumor, and adjacent organ involvement are significant with respect to the time for recurrence of colorectal cancer. It is important to take these characteristics into account in patient care management after curative resection for colorectal cancer.
Published in Asia-Pacific journal of clinical oncology
Published in Asia-Pacific journal of clinical oncology
Advances in understanding the biology and genetics of renal-cell carcinomas have led to the development of novel targeted therapies for the treatment of metastatic renal-cell cancer. Previously the systemic approaches were limited to cytokine therapies that were modest in their clinical benefits and at the expense of significant toxicities. Investi...
Published in Asia-Pacific journal of clinical oncology
Our results indicate that CT/RT followed by surgery can significantly improve OS and TFS, and may be considered as an optimal option in treatment of patients with superior sulcus NSCLC.
Published in Asia-Pacific journal of clinical oncology
The MMHM project was a successful pilot of a mentoring program in hematological cancers between metropolitan and regional centers that resulted in improved referral links, facilitated better care coordination, updated treatment policies and guidelines and increased clinician satisfaction and knowledge.
