Ouboussad, L. Hunt, L. Hensor, E. M. A. Nam, J. L. Barnes, N. A. Emery, P. McDermott, M. F. Buch, M. H.
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Arthritis Research & Therapy
BackgroundIndividuals at risk of rheumatoid arthritis (RA) demonstrate systemic autoimmunity in the form of anti-citrullinated peptide antibodies (ACPA). MicroRNAs (miRNAs) are implicated in established RA. This study aimed to (1) compare miRNA expression between healthy individuals and those at risk of and those that develop RA, (2) evaluate the c...
Ghosh, Nilasha Ruderman, Eric M.
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Arthritis Research & Therapy
Current classification criteria for axial spondyloarthritis (axSpA) provide for the inclusion of patients with a wide range of presentations and manifestations. While not considered a formal subclassification, patients are often divided into radiographic or nonradiographic axSpA based on the presence or absence of radiographic sacroiliitis. This re...
Pavelka, Karel Kivitz, Alan Dokoupilova, Eva Blanco, Ricardo Maradiaga, Marco Tahir, Hasan Pricop, Luminita Andersson, Mats Readie, Aimee Porter, Brian
...
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Arthritis Research & Therapy
BackgroundSecukinumab, an anti–interleukin-17A monoclonal antibody, improved the signs and symptoms of ankylosing spondylitis (AS) in two phase 3 studies (MEASURE 1 and MEASURE 2). Here, we present 52-week results from the MEASURE 3 study assessing the efficacy and safety of secukinumab 300 and 150 mg subcutaneous maintenance dosing, following an i...
Ferreira, Isabel Croca, Sara Raimondo, Maria Gabriella Matharu, Manjit Miller, Sarah Giles, Ian Isenberg, David Ioannou, Yiannis Hanly, John G. Urowitz, Murray B.
...
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Arthritis Research & Therapy
BackgroundIn patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN...
Hou, Sheng-Mou Hou, Chun-Han Liu, Ju-Fang
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Arthritis Research & Therapy
BackgroundOsteoarthritis (OA) is a degenerative joint disease that affects the cartilage, synovium, and subchondral bone and is the leading cause of disability in older populations. Specific diagnostic biomarkers are lacking; hence, treatment options for OA are limited. Synovial inflammation is very common in OA joints and has been associated with ...
Reiseter, Silje Gunnarsson, Ragnar Corander, Jukka Haydon, Joanna Lund, May Brit Aaløkken, Trond Mogens Taraldsrud, Eli Hetlevik, Siri Opsahl Molberg, Øyvind
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Arthritis Research & Therapy
BackgroundThe phenotypic stability of mixed connective tissue disease (MCTD) is not clear, and knowledge about disease activity and remission is scarce. We aimed to establish the occurrence of evolution from MCTD to another defined rheumatic condition, and the prevalence and durability of remission after long-term observation.MethodsIn this large p...
Stamp, Lisa K. Chapman, Peter T. Barclay, Murray Horne, Anne Frampton, Christopher Tan, Paul Drake, Jill Dalbeth, Nicola
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Arthritis Research & Therapy
BackgroundThe use of allopurinol in people with chronic kidney disease (CKD) remains one of the most controversial areas in gout management. The aim of this study was to determine the effect of baseline kidney function on safety and efficacy of allopurinol dose escalation to achieve serum urate (SU)
Sarmanova, Aliya Hall, Michelle Fernandes, Gwen S. Bhattacharya, Archan Valdes, Ana M. Walsh, David A. Doherty, Michael Zhang, Weiya
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Arthritis Research & Therapy
BackgroundAn important role for synovial pathology in the initiation and progression of knee osteoarthritis has been emphasised recently. This study aimed to examine whether ultrasonography-detected synovial changes associate with knee pain (KP) in a community population.MethodsA case–control study was conducted to compare people with early KP (n =...
Wei, Jian-lu Fu, Wenyu Ding, Yuan-jing Hettinghouse, Aubryanna Lendhey, Matin Schwarzkopf, Ran Kennedy, Oran D. Liu, Chuan-ju
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Arthritis Research & Therapy
BackgroundAtsttrin, an engineered protein composed of three tumor necrosis factor receptor (TNFR)-binding fragments of progranulin (PGRN), shows therapeutic effect in multiple murine models of inflammatory arthritis . Additionally, intra-articular delivery of PGRN protects against osteoarthritis (OA) progression. The purpose of this study is to det...
Sanges, Sébastien Giovannelli, Jonathan Sobanski, Vincent Morell-Dubois, Sandrine Maillard, Hélène Lambert, Marc Podevin, Céline Lamblin, Nicolas De Groote, Pascal Bervar, Jean-François
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Arthritis Research & Therapy
BackgroundThere is an ongoing debate regarding the relevance of the 6-minute walking distance (6MWD) in systemic sclerosis (SSc) assessment, widely used as a usual test in these patients as well as an outcome measure in clinical trials. In this work, we aimed to assess the associations between the 6MWD and various disease parameters in patients wit...