van Hoeven, Lonneke Boonen, Annelies E. R. C. H. Hazes, Johanna M. W. Weel, Angelique E. A. M.
Published in
Arthritis Research & Therapy
BackgroundTo understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP).MethodsData were used from a primary care CLBP cohort that was established to understand the prevalence of nr-axSpA and AS. ...
Artlett, Carol M. Sassi-Gaha, Sihem Hope, Jennifer L. Feghali-Bostwick, Carol A. Katsikis, Peter D.
Published in
Arthritis Research & Therapy
BackgroundDespite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expression can be induced with interleukin (IL)-1β. SSc fibroblasts have activated inflammasomes that are integrall...
Cabrera-Villalba, Sonia Gomara, María José Cañete, Juan D. Ramírez, Julio Salvador, Georgina Ruiz-Esquide, Virginia Hernández, Maria Victoria Inciarte-Mundo, José Haro, Isabel Sanmartí, Raimon
...
Published in
Arthritis Research & Therapy
BackgroundTo analyze differences in the recognition of anti-citrullinated peptide/protein antibody (ACPA) citrullinated epitopes and isotypes in patients with palindromic rheumatism (PR) and rheumatoid arthritis (RA).MethodsACPA fine specificities (citrullinated peptides of enolase, fibrin, and vimentin) and isotypes (IgG, IgM, and IgA) were analyz...
Oke, Vilija Brauner, Susanna Larsson, Anders Gustafsson, Johanna Zickert, Agneta Gunnarsson, Iva Svenungsson, Elisabet
Published in
Arthritis Research & Therapy
BackgroundInterferon (IFN)-α is thought to have a pivotal role in systemic lupus erythematosus (SLE), and type III IFNs (IFN-λ) were recently also associated with SLE. In this study, we measured levels of IFN-α, IFN-λ1, and related cytokines, such as IL-17A, IL-23, and interferon-γ-induced protein 10 (IP-10), in a Karolinska University Hospital coh...
Hartl, Agnes Sieper, Joachim Syrbe, Uta Listing, Joachim Hermann, Kay-Geert Rudwaleit, Martin Poddubnyy, Denis
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Arthritis Research & Therapy
BackgroundPrevious research indicates a role of adipokines in inflammation and osteogenesis. Hence adipokines might also have a pathophysiological role in inflammation and new bone formation in patients with ankylosing spondylitis (AS). The aim of this study was to investigate the role of adipokine serum levels as predictors of radiographic spinal ...
Aterido, Adrià Julià, Antonio Carreira, Patricia Blanco, Ricardo López-Longo, José Javier Venegas, José Javier Pérez Olivé, Àlex Andreu, José Luís Aguirre-Zamorano, Maria Ángeles Vela, Paloma
...
Published in
Arthritis Research & Therapy
BackgroundSystemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a genetic basis for SLE heterogeneity. The objective of the present study was to identify new genetic variation associated with the clinica...
Sucur, Alan Jajic, Zrinka Artukovic, Marinko Matijasevic, Marina Ikic Anic, Branimir Flegar, Darja Markotic, Antonio Kelava, Tomislav Ivcevic, Sanja Kovacic, Natasa
...
Published in
Arthritis Research & Therapy
BackgroundThe peripheral blood (PB) monocyte pool contains osteoclast progenitors (OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by the cytokine and chemokine milieu. We aimed to define the importance of chemokine signals for migration and activation of OCPs in rheumatoid arthritis (RA) and psoriatic arth...
Lintermans, Lucas L. Rutgers, Abraham Stegeman, Coen A. Heeringa, Peter Abdulahad, Wayel H.
Published in
Arthritis Research & Therapy
BackgroundPersistent expansion of circulating CD4+ effector memory T cells (TEM) in patients with granulomatosis with polyangiitis (GPA) suggests their fundamental role in disease pathogenesis. Recent studies have shown that distinct functional CD4+ TEM cell subsets can be identified based on expression patterns of chemokine receptors. The current ...
Urushima, Hayato Fujimoto, Minoru Mishima, Takashi Ohkawara, Tomoharu Honda, Hiromi Lee, Hyun Kawahata, Hirohisa Serada, Satoshi Naka, Tetsuji
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Arthritis Research & Therapy
BackgroundLeucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transforming growth factor (TGF)-β and enhances Smad2 phosphorylation. Considering that the imbalance between T helper 17 (Th17) cells and re...
Guillén-Del Castillo, Alfredo Callejas-Moraga, Eduardo L. García, Gabriela Rodríguez-Palomares, José F. Román, Antonio Berastegui, Cristina López-Meseguer, Manuel Domingo, Enric Fonollosa-Plá, Vicente Simeón-Aznar, Carmen Pilar
...
Published in
Arthritis Research & Therapy
BackgroundPulmonary arterial hypertension (PAH) is one of the most relevant causes of death in systemic sclerosis. The aims of this study were to analyse the recently published DETECT algorithm comparing it with European Society of Cardiology/European Respiratory Society (ESC/ERS) 2009 guidelines: as screening of PAH; (2) identifying median pulmona...
