Jonsson, Maria Karolina Hensvold, Aase Haj Hansson, Monika Aga, Anna-Birgitte Sexton, Joseph Mathsson-Alm, Linda Cornillet, Martin Serre, Guy Lillegraven, Siri Fevang, Bjørg-Tilde Svanes
...
Published in
Arthritis Research & Therapy
BackgroundAnti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities in an inception cohort of patien...
Yang, Qibin Zhang, Quanbo Qing, Yufeng Zhou, Li Mi, Qingsheng Zhou, Jingguo
Published in
Arthritis Research & Therapy
BackgroundThe findings of a previous study by Jin et al. have shown that microRNA (miR)-155 was upregulated in patients with acute gouty arthritis and enhanced the proinflammatory cytokines. There is no direct evidence to support that miR-155 is indeed involved in monosodium urate (MSU)-induced inflammatory responses in vivo. The aim of this study ...
Pisaniello, Huai Leng Lester, Susan Gonzalez-Chica, David Stocks, Nigel Longo, Marie Sharplin, Greg R. Dal Grande, Eleonora Gill, Tiffany K. Whittle, Samuel L. Hill, Catherine L.
...
Published in
Arthritis Research & Therapy
BackgroundGout has an increasing global prevalence. Underutilization of urate-lowering therapy (ULT) is thought to be common, via both suboptimal dosing and poor medication adherence. The aims of this study were to determine the prevalence of self-reported gout and the key predictors of ULT use in those with gout in a representative population surv...
Wang, Yilun Chen, Shuang Chen, Sunyi Du, Juan Lin, Jinran Qin, Haihong Wang, Jie Liang, Jun Xu, Jinhua
Published in
Arthritis Research & Therapy
BackgroundMonocyte-derived dendritic cells (moDCs) play important roles in the pathogenesis of systemic lupus erythematosus (SLE). Aberrant expression of long noncoding RNAs (lncRNAs) could affect the function of moDCs. The aim of this study was to explore the lncRNA expression profile in moDCs of SLE patients to provide new insights into SLE.Metho...
Zhao, Sizheng Thong, Daniel Miller, Natasha Duffield, Stephen J. Hughes, David M. Chadwick, Laura Goodson, Nicola J.
Published in
Arthritis Research & Therapy
BackgroundDepression is common among patients with axial spondyloarthritis (axSpA), but reports of its prevalence are highly variable. We performed a systematic review to (i) describe the prevalence of depression in axSpA, (ii) compare its prevalence between axSpA, ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA) cohorts, and (iii)...
Weiss, Pamela F. Xiao, Rui Brandon, Timothy G. Biko, David M. Maksymowych, Walter P. Lambert, Robert G. Jaremko, Jacob L. Chauvin, Nancy A.
Published in
Arthritis Research & Therapy
BackgroundWe aimed to evaluate the diagnostic utility of pelvic radiographs versus magnetic resonance imaging (MRI) of the sacroiliac joints in children with suspected sacroiliitis.MethodsThis was a retrospective cross-sectional study of children with suspected or confirmed spondyloarthritis who underwent pelvic radiograph and MRI within 6 months o...
Korman, Benjamin Marangoni, Roberta Goncalves Lord, Gabriel Olefsky, Jerrold Tourtellotte, Warren Varga, John
Published in
Arthritis Research & Therapy
BackgroundA pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis. Peroxisome proliferator activated receptor-γ (PPAR-γ) has antifibrotic effects by blocking transforming growth factor-β (TGF-β) and is dysregulated in SSc....
Donlin, Laura T. Rao, Deepak A. Wei, Kevin Slowikowski, Kamil McGeachy, Mandy J. Turner, Jason D. Meednu, Nida Mizoguchi, Fumitaka Gutierrez-Arcelus, Maria Lieb, David J.
...
Published in
Arthritis Research & Therapy
BackgroundDetailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims to deconstruct autoimmune pathology by examining cells within target tissues through multiple high-dimensional...
Kwon, Oh Chan Lee, Sang-Won Park, Yong-Beom Oh, Ji Seon Lee, Sang Hoon Hong, Seokchan Lee, Chang-Keun Yoo, Bin Kim, Yong-Gil
Published in
Arthritis Research & Therapy
BackgroundTakayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to ident...
Tseng, Chia-Chun Chen, Chung-Jen Yen, Jeng-Hsien Huang, Hsi-Yuan Chang, Jan-Gowth Chang, Shun-Jen Liao, Wei-Ting
Published in
Arthritis Research & Therapy
BackgroundAccumulating evidence implicates mitochondrial DNA (mtDNA) alleles, which are independent of the nuclear genome, in disease, especially in human metabolic diseases. However, this area of investigation has lagged behind in researching the nuclear alleles in complex traits, for example, in gout.MethodsNext-generation sequencing was utilized...
