Shin, Sooim Davidson, Victor L.
Published in
Archives of Biochemistry and Biophysics
MauG contains two c-type hemes with atypical physical and catalytic properties. While most c-type cytochromes function simply as electron transfer mediators, MauG catalyzes the completion of tryptophan tryptophylquinone (TTQ)1Abbreviations used: TTQ, tryptophan tryptophylquinone; DCCPs, diheme cytochrome c peroxidases; MADH, methylamine dehydrogena...
Harrison, Peter J. Bugg, Timothy D.H.
Published in
Archives of Biochemistry and Biophysics
Carotenoid cleavage dioxygenases (CCDs) are a large family of non-heme iron (II) dependent enzymes. CCDs catalyse the selective oxidative cleavage of carotenoids to produce apocarotenoids. Apocarotenoid derived molecules form important signalling molecules in plants in the form of abscisic acid and strigolactone and in mammals in the form of retina...
Moran, Graham R.
Published in
Archives of Biochemistry and Biophysics
4-Hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate synthase (HMS) are outliers within the α-keto acid dependent oxygenase (αKAO) family. HPPD and HMS catalyze the chemistry of the majority of enzymes within the αKAO family but are clearly mechanistically convergent, having a grossly different structural topology. Some of the unique cha...
Gadda, Giovanni
Published in
Archives of Biochemistry and Biophysics
Allen, Kylie D. Wang, Susan C.
Published in
Archives of Biochemistry and Biophysics
Fosfomycin is a broad-spectrum antibiotic that is useful against multi-drug resistant bacteria. Although its biosynthesis was first studied over 40years ago, characterization of the penultimate methyl transfer reaction has eluded investigators. The enzyme believed to catalyze this reaction, Fom3, has been identified as a radical S-adenosyl-l-methio...
Hu, Minyi Qin, Yi-Xian
Published in
Archives of Biochemistry and Biophysics
Recently we have developed a dynamic hydraulic stimulation (DHS) as a loading modality to induce anabolic responses in bone. To further study the functional process of DHS regulated bone metabolism, the objective of this study was to evaluate the effects of DHS on cortical bone and its alterations on gene expressions of osteogenic growth factors an...
Tiago, Daniel M. Marques, Cátia L. Roberto, Vânia P. Cancela, M. Leonor Laizé, Vincent
Published in
Archives of Biochemistry and Biophysics
MicroRNAs (miRNAs) are important regulators of vertebrate development but their role during skeletogenesis remains unknown. In this regard, we investigated the mineralogenic activity of miR-20a, a miRNA associated with osteogenesis, in fish bone-derived cells. Expression of miR-20a was up-regulated during differentiation and its overexpression inhi...
Fillat, María F.
Published in
Archives of Biochemistry and Biophysics
Control of metal homeostasis is essential for life in all kingdoms. In most prokaryotic organisms the FUR (ferric uptake regulator) family of transcriptional regulators is involved in the regulation of iron and zinc metabolism through control by Fur and Zur proteins. A third member of this family, the peroxide-stress response PerR, is present in mo...
Doan, Thanh Thi Ngoc Kim, Jin-Kwang Ngo, Ho-Phuong-Thuy Tran, Huyen-Thi Cha, Sun-Shin Min Chung, Kyung Huynh, Kim-Hung Ahn, Yeh-Jin Kang, Lin-Woo
Published in
Archives of Biochemistry and Biophysics
d-Alanine-d-alanine ligase (DDL) catalyzes the biosynthesis of d-alanyl-d-alanine, an essential bacterial peptidoglycan precursor, and is an important drug target for the development of antibacterials. We determined four different crystal structures of DDL from Xanthomonas oryzae pv. oryzae (Xoo) causing Bacteria Blight (BB), which include apo, ADP...
Denison, Fiona C. Gökirmak, Tufan Ferl, Robert J.
Published in
Archives of Biochemistry and Biophysics
14-3-3 proteins are generally believed to function as dimers in a broad range of eukaryotic signaling pathways. The consequences of altering dimer stability are not fully understood. Phosphorylation at Ser58 in the dimer interface of mammalian 14-3-3 isoforms has been reported to destabilise dimers. An equivalent residue, Ser62, is present across m...
