Published in Annals of clinical biochemistry
There is a direct positive association between glycaemic control and renin. We advocate for renin measurement to be part of the diabetologist's armamentarium to assess, guide and optimise therapeutic strategies in patients with diabetes.
Published in Annals of clinical biochemistry
We report a 70-year-old female presenting with increased libido and mild but rapid onset virilism. Investigations showed markedly elevated androstenedione and 17 hydroxyprogesterone misdirecting to possible late-onset congenital adrenal hyperplasia. High serum testosterone and oestrogens with suppressed gonadotrophins, however, indicated an androge...
Published in Annals of clinical biochemistry
A positive association between plasma PCSK9 concentration and CAC in untreated patients with angina-like chest pain was observed in our study, suggesting further investigation may be needed in order to confirm our primary findings and explore the clinical implications.
Published in Annals of clinical biochemistry
We report a 70-year-old female presenting with increased libido and mild but rapid onset virilism. Investigations showed markedly elevated androstenedione and 17 hydroxyprogesterone misdirecting to possible late-onset congenital adrenal hyperplasia. High serum testosterone and oestrogens with suppressed gonadotrophins, however, indicated an androge...
Published in Annals of clinical biochemistry
The human precorneal tear film (PCTF) is a special body fluid, since it is a complex mixture of proteins, lipids small bioactive molecules and their concentrations and relative distribution represent not only the metabolic state of the ocular surface but also the systemic and local homeostasis of the outer eye and the human body. This suggests that...
Published in Annals of clinical biochemistry
Background We have reported that the blood glucose normalization treatment reduced the albumin glycation sites and the intensity of albumin AGE fluorescence in patients with abnormally high glycated albumin levels. To clarify the relationship between glycaemic control status and levels of glycated proteins and related markers, we studied the change...
Published in Annals of clinical biochemistry
The Abbott Architect i1000® estradiol assay exhibits greater agreement with LC-MS/MS and exhibited better correlation to follicular volume when estradiol values are >1000pg/mL (3,670 pmol/L), prompting a change in the clinic's estradiol platform. Attention to assay quality assurance via LC-MS/MS can improve estradiol accuracy and permit more inform...
Published in Annals of clinical biochemistry
Using the oxidative assay provides a cost-effective means of estimating caeruloplasmin levels. The method is easily adaptable to a 96-well plate format that facilitates high throughput of samples in a busy laboratory. The enzymatic method is more sensitive and specific for differentiating between Wilson's and non-Wilson's when compared to immunoass...
Published in Annals of clinical biochemistry
Background Healthcare budgets face constraints, and laboratories have developed strategies to adapt to the concomitant increase in workload. Some of the tests (7.4%) may be attributed to unnecessary repeat testing. Electronic gatekeeping has been implemented at selected laboratories in South Africa to limit unnecessary repeat testing. We performed ...
Published in Annals of clinical biochemistry
Background Measured (MO) and calculated osmotic concentrations (CO) and the osmotic gap (OG) are commonly used in the investigation of electrolyte and volume disturbances as well as in cases of suspected volatile ingestion. Methods We compared 38 published formulae for CO with MO on a large data-set ( n = 9466) and adjusted the CO with the result o...
