Du, Guanqun Belić, Domagoj Del Giudice, Alessandra Alfredsson, Viveka Carnerup, Anna M. Zhu, Kaizheng Nyström, Bo Wang, Yilin Galantini, Luciano Karin Schillén
...
Published in
Angewandte Chemie International Edition
Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA-like condensation with supramolecular helices of sma...
Chawla, Udeep Perera, Suchithranga M D C Fried, Steven D E Eitel, Anna R Mertz, Blake Weerasinghe, Nipuna Pitman, Michael C Struts, Andrey V Brown, Michael F
Published in
Angewandte Chemie (International ed. in English)
Visual rhodopsin is an important archetype for G-protein-coupled receptors, which are membrane proteins implicated in cellular signal transduction. Herein, we show experimentally that approximately 80 water molecules flood rhodopsin upon light absorption to form a solvent-swollen active state. An influx of mobile water is necessary for activating t...
Suchithranga Perera Chawla, Udeep Perera, Suchithranga M. D. C. Fried, Steven D. E. Eitel, Anna R. Mertz, Blake Nipuna Weerasinghe Pitman, Michael C. Struts, Andrey V. Brown, Michael F.
...
Published in
Angewandte Chemie International Edition
Visual rhodopsin is an important archetype for G‐protein‐coupled receptors, which are membrane proteins implicated in cellular signal transduction. Herein, we show experimentally that approximately 80 water molecules flood rhodopsin upon light absorption to form a solvent‐swollen active state. An influx of mobile water is necessary for activating t...
Vance, Nicholas R Gakhar, Lokesh Spies, M Ashley
Published in
Angewandte Chemie (International ed. in English)
The caspase family of cysteine proteases are highly sought-after drug targets owing to their essential roles in apoptosis, proliferation, and inflammation pathways. High-throughput screening efforts to discover inhibitors have gained little traction. Fragment-based screening has emerged as a powerful approach for the discovery of innovative drug le...
Liu, Xiaoqing Savy, Alexandra Maurin, Sylvie Grimaud, Laurence François Darchen Quinton, Damien Eric Labbe Buriez, Olivier Delacotte, Jérôme Lemaître, Frédéric
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Published in
Angewandte Chemie International Edition
In this work, Fluorescent False Neurotransmitter 102 (FFN102), a synthesized analogue of biogenic neurotransmit-ters, was demonstrated to show both pH-dependent fluores-cence and electroactivity. To study secretory behaviors at the single-vesicle level, FFN102 was employed as a new fluores-cent/electroactive dual probe in a coupled technique (amper...
Li, Anyin Baird, Zane Bag, Soumabha Sarkar, Depanjan Prabhath, Anupama Pradeep, Thalappil Cooks, R Graham
Published in
Angewandte Chemie International Edition
Electrolytic spray deposition was used to pattern surfaces with 2D metallic nanostructures. Spots that contain silver nanoparticles (AgNP) were created by landing solvated silver ions at desired locations using electrically floated masks to focus the metal ions to an area as little as 20 μm in diameter. The AgNPs formed are unprotected and their ag...
Lee, Jae-Hyun Chen, Kuan-Ju Noh, Seung-Hyun Garcia, Mitch André Wang, Hao Lin, Wei-Yu Jeong, Heeyeong Kong, Brian Junoh Stout, David B Cheon, Jinwoo
...
Published in
Angewandte Chemie (International ed. in English)
Shuang Hou Zhao, Libo QingLin Shen Yu, Juehua Ng, Charles Kong, Xiangju Dongxia Wu Min Song Shi, Xiaohong Xu, Xiaochun
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Published in
Angewandte Chemie International Edition
Li, Yuanpei Xiao, Wenwu Xiao, Kai Berti, Lorenzo Luo, Juntao Tseng, Harry P Fung, Gabriel Lam, Kit S
Published in
Angewandte Chemie (International ed. in English)
Kinsella, Joseph M Jimenez, Rebecca E Karmali, Priya P Rush, Anthony M Kotamraju, V Ramana Gianneschi, Nathan C Ruoslahti, Erkki Stupack, Dwayne Sailor, Michael J
Published in
Angewandte Chemie (International ed. in English)
