Li, Yaqin Cheng, Xianyi Chen, Yihua Zhou, Tao Li, Dezhi Zheng, Wei V
Published in
American Journal of Translational Research
Objective: To explore whether METTL3 was involved in the pathogenesis of hepatocellular carcinoma (HCC) by modulating the m6A level of USP7. Methods: We performed qRT-PCR and western blot assays to detect the expression level of METTL3 in HCC tissues and paired adjacent normal tissues, as well as HCC cell lines. The level of m6A in HCC tissues and ...
Liu, Li Deng, Yu-Qin Jiao, Wo-Er Qiao, Yue-Long Tao, Ze-Zhang Wang, Yong Hua, Qing-Quan Chen, Shi-Ming
Published in
American Journal of Translational Research
Background and objective: Maggots are the larval stage of Lucilia sericata and have strong antibacterial activity and immunomodulatory effects. The objective of our study was to investigate whether maggot extracts can modulate regulatory T cells (Tregs) and treat allergic rhinitis (AR). Methods: Mice were randomly assigned to five groups (n=6/group...
Zhang, Feiyue Duan, Bide Liu, Yanming Wang, Cuicui
Published in
American Journal of Translational Research
Objective: To determine the clinical efficacy of aspirin combined with labetalol on gestational hypertension (GH) and its influence on serum pregnancy associated plasma protein-A (PAPP-A), adiponectin (APN), and high mobility group box-1 (HMGB1). Methods: A total of 146 patients with GH admitted to the Zibo Central Hospital between April 2018 and J...
Liu, Junjie Mu, Hong Zhang, Weidong
Published in
American Journal of Translational Research
Purpose: To investigate the clinical diagnosis, treatment, and complication prevention of carotid body tumors (CBTs). Methods: The medical records of 24 patients with CBTs treated in the Department of Oral and Maxillofacial Surgery in Shandong Provincial Hospital Affiliated to Shandong First Medical University from 1999 to 2014 were reviewed. All t...
Wei, Shengchao Xi, Jie Cao, Shuai Li, Tao Xu, Jiacheng Li, Wei Bi, Yuhe
Published in
American Journal of Translational Research
Objective: To explore the clinical efficacy of laparoscopic radical resection combined with neoadjuvant chemotherapy (NACT) in the treatment of colorectal cancer and its influence on postoperative complications. Methods: The clinical data of 90 patients with colorectal cancer admitted to our hospital from June 2019 to June 2021 were retrospectively...
Chen, Chun Zhu, Yiyi Chen, Yan Wang, Zengjun Zhao, Liandong
Published in
American Journal of Translational Research
Objective: Acute cerebral infarction (ACI) can lead to death or disability, posing a serious threat to human health. This study aimed to investigate the effects of cerebral artery thrombectomy on the efficacy, safety, cognitive function and peripheral blood amyloid-β (Aβ), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in patients ...
Nie, Junfeng Su, Xiaoqian Wei, Li Li, Hua
Published in
American Journal of Translational Research
Objective: To investigate the role of early enteral nutrition support (ENN) on the improvement of immune function and physical recovery of patients with colon carcinoma. Methods: The patients with colon carcinoma treated in our hospital from November 2018 to November 2019 were obtained and randomly grouped into the control group (CG) and the early ...
Zhou, Junde Wang, Linna Cui, Yunfu Tang, Lanhua
Published in
American Journal of Translational Research
Objective: To explore the regulation of miR-125a-5p in hepatocellular carcinoma (HCC) and its mechanisms. Methods: By transfecting a miR-125a-5p sequence and an interfering sequence of miR-125a-5p-s into human HCC cell lines HCC-LM3 and HepG2, miR-125a-5p-related levels were assesed by Western blot. The abilities of cell proliferation and migration...
Niu, Changchun Wu, Di Li, Alexander J Qin, Kevin H Hu, Daniel A Wang, Eric J Tucker, Andrew Blake He, Fang Huang, Linjuan Wang, Hao
...
Published in
American Journal of Translational Research
Objectives: Acute myeloid leukemia (AML) is caused by multiple genetic alterations in hematopoietic progenitors, and molecular genetic analyses have provided useful information for AML diagnosis and prognostication. This study aimed to integratively understand the prognostic value of specific copy number variation (CNV) patterns and CNV-modulated g...
Lei, Jun Zhou, Zhi
Published in
American Journal of Translational Research
Objective: To determine the efficacy and safety of bevacizumab (Bz) combined with temozolomide (TMZ) in the treatment of recurrent malignant gliomas and its influence on serum tumor markers (STMs). Methods: The clinical data of 73 patients with recurrent malignant gliomas admitted to the First People’s Hospital of Shuangliu District from April 2016...
