Wang, Lixia Wang, Yiwen Han, Tuo Li, Ying Zhang, Ting Ma, Weidong Zhang, Yan Zhang, Chunyan Wang, Congxia
Published in
American Journal of Translational Research
Background: The prevalence of hypertension and obesity in China has sharply increased in recent decades. We aimed to develop and validate a novel model for predicting the risk of hypertension based on anthropometric indicators relating to obesity in the general population of China. Methods: In this retrospective study, 6196 participants from the Ch...
Quan, Lijuan Zhao, Yue Ouyang, Chengfeng Ying, Dexia Xiong, Zhichao Li, Xunxin Liao, Ziqin Luo, Jun Liu, Howe
Published in
American Journal of Translational Research
Objective: To investigate the role of chemokine receptor ACKR2 in cognitive impairment in young rats with traumatic brain injury. Methods: Seventy-five young rats were randomly divided into TBI group, TBI+Negative control (NC) group, TBI+Sensory integration (SI) group, TBI+Atypical chemokine receptor 2 (ACKR2) group and TBI+SI+ACKR2 group. We emplo...
Tong, Feng Yang, Huifang Pan, Haihua Zhang, Longfei Zhang, Xia
Published in
American Journal of Translational Research
Objective: To investigate the application effect of the county medical community Hospital-Community health service organization-Home (HCH) model in nutritional management of patients with advanced gastrointestinal cancer after surgery. Methods: This is a retrospective study. A total of 100 postoperative malnutrition patients with advanced gastroint...
Chen, Guangren Zhang, Xiaopan Chen, Fengling
Published in
American Journal of Translational Research
Objective: To investigate whether the gut microbiota differs in patients with chronic kidney disease receiving kidney transplant or hemodialysis, and to explore the relationship between the gut microbiota and clinical indicators. Methods: A total of 72 patients with kidney transplantation (RT) and 78 patients with hemodialysis (HD) admitted to the ...
Liu, Shiping Chen, Long Zeng, Jing Chen, Yuhua
Published in
American Journal of Translational Research
Background: Gastric cancer (GC) is one of the most common malignancies worldwide with a poor prognosis due to the lack of early detection and effective treatments. As a biomarker, collagen type I alpha 1 (COL1A1) is often dysregulated in some cancer types. However, the expression profile of COL1A1 and functional mechanism in GC is still unclear. Me...
Wang, Ying Xiao, Chanyun Zhang, Na Sun, Guoqiang
Published in
American Journal of Translational Research
Objective: Bakri balloon tamponade (BBT) is currently being used worldwide. This study aimed to explore the real-world performance of BBT for the treatment of postpartum hemorrhage (PPH). Methods: A total of 279 women with PPH who failed to respond to first-line conservative management and received BBT were consecutively recruited, reflecting authe...
Gan, Yaping Feng, Weifeng Xu, Liben Guo, Xinwei Wang, Yan Chen, Zhifu Zhu, Lihua Wu, Chaoyang Ning, Yingxia
Published in
American Journal of Translational Research
Aim: To develop a miRNA-205 based model for prediction of the recurrence of endometrial cancer. Methods: The FIGO (International Federation of Gynecology and Obstetrics) stage, grading, myometrial infiltration, lymph node status and miRNA-205 expression levels were extracted from 90 endometrioid endometrial cancer patients, recurrence related risk ...
Tian, Jiahui Fu, Chunyan Peng, Qian Yang, Jialu Fan, Xiaoxiao Zeng, Xuan Qing, Weiguo Wu, Yi
Published in
American Journal of Translational Research
Objectives: The immune cell infiltration (ICI) in the tumor microenvironment (TME) can provide a reference for prognosis after immunotherapy. We aim to establish an ICI scoring model and evaluate its predictive ability for the immunotherapy efficacy and the prognosis in lung adenocarcinoma (LUAD) patients. Methods: We developed and analyzed the lan...
Ji, Xiaolei Chen, Haiyun Liu, Boyang Zhuang, Hai Bu, Shoushan
Published in
American Journal of Translational Research
Objectives: Bmi1 deficiency has been proved to be able to cause mandibular osteoporosis through suppressing oxidative stress. However, the role of DNA damage response pathway in this pathogenesis had not been well understood. In this study, we investigate whether mandibular osteoporosis induced by Bmi1 deficiency could be rescued by blocked DNA dam...
Xia, Yijun Wang, Youbin Hao, Yan Shan, Mengjie Liu, Hao Liang, Zhengyun
Published in
American Journal of Translational Research
Objectives: To identify aberrantly expressed immune molecules in keloids and to explore their possible biologic significance. Methods: Immune molecules with abnormal expression were identified based on immune gene sequencing of keloids, microarray datasets and high-throughput sequencing datasets and methylation microarray datasets from the Gene Exp...
