Shen, Kaiyi Jiang, Shenbei
Published in
American Journal of Translational Research
Objective: To explore the value of procalcitonin (PCT) and brain natriuretic peptide (BNP) in predicting the prognosis of sepsis. Methods: A total of 65 patients with sepsis received treatment in Deqing County People’s Hospital from 2019 January and 2021 January and their data were collected retrospectively. Based on the survival and death of patie...
Lai, Jiying Shen, Enfang Yue, Linlin Zhong, Huifeng Liu, Xin Yin, Kang
Published in
American Journal of Translational Research
Objective: To explore the mechanism by which mechanical ventilation improves myocardial injury in rats with acute heart failure (AHF). Methods: Thirty-six male Sprague Dawley rats were randomized into a sham group, heart failure (HF) group, and mechanical ventilation (MV) group. The AHF rat model was established by pentobarbital perfusion under rig...
Deng, Jing Wu, Maolin
Published in
American Journal of Translational Research
Background: COX10-AS1 belongs to the class of lncRNA and has been shown to influence carcinogenesis; however, its function and underlying mechanism in oral squamous cell carcinoma are still unclear (OSCC). Method: Western blotting, immunohistochemistry, and RT-PCR were used to identify gene expression. Cell invasion and migration were discovered us...
Kim, Bong-Kyu Lee, Sung Jin Kim, Tae-Woo Kim, Hyojung Lee, Hyunjung Hong, Eun Young Cho, Yang Je Kwon, Sunjong Kim, Seok-Hyun
Published in
American Journal of Translational Research
Objectives: EGT022, an RGD-containing recombinant disintegrin from human ADAM metallopeptidase domain 15 (ADAM15), has been reported to stimulate vascular maturation of retinal blood vessels with promotion of pericyte coverage through binding to integrin αIIbβ3. Previous studies have reported that angiogenesis can be inhibited by several RGD motif-...
Zhao, Junde Jiao, Wenjian Sui, Xiaohui Zou, Jiani Wang, Jiuling Lin, Zhiheng
Published in
American Journal of Translational Research
Objective: Endometrial cancer is one of the most common tumors of the female reproductive system, and the existing treatment options for advanced and metastatic endometrial cancer have certain limitations. The antitumor activity of luteolin has been gradually discovered. The purpose of this study was to predict the potential of luteolin in the trea...
Wang, Jingpu Chen, Xue Zhao, Yipeng
Published in
American Journal of Translational Research
Background: Objective: The aim of this study was to analyze the role of blood Glucagon like peptide-1 (GLP-1), insulin-like growth element-1 (IGF-1), and type 2 diabetes mellitus (T2DM) in coronary heart disease (CHD). Method: In this study, the clinical data of T2DM patients (n=203) admitted to Baoding Second Hospital from June 2020 to June 2021 w...
Kulshrestha, Ritu Negi, Amandeep Bhutani, Ishita Saxena, Himanshi Rani, Meenu Menon, Balakrishnan Kaushik, Rajnish Pandita, Sunil Kumar, Raj
Published in
American Journal of Translational Research
Background: Tumor cell phagocytosis (cannibalism) is rarely seen in lung carcinomas. Little is known about its underlying cellular pathogenesis and associated significance as tumor immune escape mechanism. Methodology: The cases of lung cancer diagnosed at department of Pathology, VPCI over 13-year period, 2007-2020 (n = 350) were retrospectively r...
Li, Guangyao Javed, Muhammad Rasool, Rubab Abdel-Maksoud, Mostafa A Mubarak, Ayman S Studenik, Christian R Narayanan, J Atuahene, Sampson Agyapong Aufy, Mohammed Cao, Kun
...
Published in
American Journal of Translational Research
Objectives: Cancer is one of the most prominent causes of death world wide. Identification of novel cancer biomarkers woud help with cancer diagnosis and possible treatment. Methods: In this study, we comprehensively studied the diagnostic, prognostic, and therapeutic values of the hepatitis A virus cellular receptor 1 (HAVCR1) gene across multiple...
Song, Yinsen Gao, Na Yang, Zhenzhen Zhang, Lu Wang, Yijia Zhang, Sisen Fan, Tianli
Published in
American Journal of Translational Research
Macrophages are the core of the pathophysiology of rheumatoid arthritis (RA). They participate in specific and non-specific immunological responses, have phagocytosis, chemotaxis and immune regulatory functions, and are involved in the onset and progression of RA. In recent years, research on the pathophysiology of RA has focused on the polarizatio...
Du, Jiangfeng Li, Ji Tan, Jianjun Yan, Yi
Published in
American Journal of Translational Research
Objective: To investigate the effect of scutellarin on the proliferation of glioma cells through microRNA (miR)-15a. Methods: Human glioma cell line T98G was cultured in vitro and divided into control group (without treatment), scutellarin group (with 10, 20, 40, 80, 160 μg/mL scutellarin, respectively), miR-15a negative control group (transfected ...
