Lipecka, Joanna Bali, Moëz Thomas, Annick Fanen, Pascale Aleksander Edelman Fritsch, Janine
Published in
American Journal of Physiology-Cell Physiology
The ubiquitous ClC-2 Cl(-) channel is thought to contribute to epithelial Cl(-) secretion, but the distribution of the ClC-2 protein in human epithelia has not been investigated. We have studied the distribution of ClC-2 in adult human and rat intestine and airways by immunoblotting and confocal microscopy. In the rat, ClC-2 was present in the late...
Provost, Nicolas Moreau, Marielle Armelle Leturque Nizard, Carine
Published in
American Journal of Physiology-Cell Physiology
Ultraviolet A (UVA) (320-400 nm) radiation is known to cause cutaneous aging and skin cancer. We studied the effect of UVA (365 nm) radiation on the human epidermis by focusing on keratinocyte gap junction-mediated intercellular communication (GJIC). We observed a dose-dependent 10-fold decrease in GJIC induced by UVA in normal human keratinocytes....
Baudouin-Legros, Maryvonne Brouillard, Franck Tondelier, Danielle Hinzpeter, Alexandre Aleksander Edelman
Published in
American Journal of Physiology-Cell Physiology
We have previously shown that ouabain, which changes the electrochemical properties of cell membranes by inhibiting Na(+),K(+)-ATPase, induces the expression of multidrug resistance (MDR-1) gene in several human cell lines. Because the expressions of the MDR-1 and CFTR (which encodes the cAMP-activated Cl(-) channel associated with cystic fibrosis)...
Baudouin-Legros, Maryvonne Hinzpeter, Alexandre Jaulmes, Amandine Brouillard, Franck Costes, Bruno Fanen, Pascale Aleksander Edelman
Published in
American Journal of Physiology-Cell Physiology
Expression of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene, which contains the mutations responsible for CF, is regulated by cytokines (TNF-alpha and IL-1beta) in a cell-specific manner. TNF-alpha decreases CFTR mRNA in human colon cell lines (HT-29), but not in pulmonary cell lines (Calu-3), and IL-1beta increases it on...
Hinzpeter, Alexandre Lipecka, Joanna Brouillard, Franck Baudoin-Legros, Maryvonne Dadlez, Michal Aleksander Edelman Fritsch, Janine
Published in
American Journal of Physiology-Cell Physiology
The voltage-dependent ClC-2 chloride channel has been implicated in a variety of physiological functions, including fluid transport across specific epithelia. ClC-2 is activated by hyperpolarization, weakly acidic external pH, intracellular Cl-, and cell swelling. To add more insight into the mechanisms involved in ClC-2 regulation, we searched for...
Brière, Jean-Jacques Favier, Judith Gimenez-Roqueplo, Anne-Paule Pierre Rustin
Published in
American Journal of Physiology-Cell Physiology
A renewed interest in tricarboxylic acid cycle enzymopathies has resulted from the report that, in addition to devastating encephalopathies, these can result in various types of tumors in human. We first review the major features of the cycle that may underlie this surprising variety of clinical features. After discussing the rare cases of encephal...
Mieulet, Virginie Roceri, Mila Espeillac, Catherine Athanassia Sotiropoulos Ohanna, Mickael Oorschot, Viola Klumperman, Judith Sandri, Marco Mario Pende
Published in
American Journal of Physiology-Cell Physiology
A defect in protein turnover underlies multiple forms of cell atrophy. Since S6 kinase (S6K)-deficient cells are small and display a blunted response to nutrient and growth factor availability, we have hypothesized that mutant cell atrophy may be triggered by a change in global protein synthesis. By using mouse genetics and pharmacological inhibito...
Fabienne Foufelle Sophie Lotersztajn Insel, Paul A Chevet, Eric
Published in
American Journal of Physiology-Cell Physiology
Editorial
Tarik Issad
Published in
American Journal of Physiology-Cell Physiology
