Galvão, Alana Alcântara de Araújo Sena, Flávia Andrade Belitardo, Emília Maria Medeiros... de Santana, Maria Borges Rabelo Costa, Gustavo Nunes de Oliveira Cruz, Álvaro Augusto Barreto, Maurício Lima Costa, Ryan dos Santos Alcantara-Neves, Neuza Maria Figueiredo, Camila Alexandrina
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Allergy, Asthma & Clinical Immunology
BackgroundVitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels of 25-hydroxyvitamin D (25(OH)D), atopy, asthma and asthma severity in teenagers from Northeast Brazil.MethodsThis is a cross secti...
Hu, Ying Chen, Zhiqiang Zeng, Jing Zheng, Shouyan Sun, Liujuan Zhu, Li Liao, Wei
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Allergy, Asthma & Clinical Immunology
BackgroundThe differentiation of CD4+ lymphocytes Th17/regulatory T cells (Treg) and indoleamine 2,3-dioxygenase (IDO) is associated with the pathogenesis of allergic asthma. Basic research has shown that IDO is likely a “switch” of the transition from Th17 cells to Tregs under certain conditions. However, no relevant clinical studies have been rep...
Jang, Dong Hyek Lee, Jae In Bae, Joo Yoon Jung, Hye Jung Park, Mi Yeon Ahn, Jiyoung
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Allergy, Asthma & Clinical Immunology
BackgroundDupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers. Recently, in addition to the treatment effects for atopic dermatitis (AD), there is an emerging adverse event as facial erythema.Case ...
Jiang, Xiao-hong Li, Chao-qian Feng, Guang-yi Luo, Ming-jie Sun, Qi-xiang
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Allergy, Asthma & Clinical Immunology
BackgroundMycobacterium vaccae nebulization imparted protective effect against allergic asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important role in allergic bronchial asthma. However, the effect of M. vaccae nebulization on the TGF-β/Smad signal transduction pathway in mouse models of allergic asthma remains uncle...
Kim, Ji Heui Kim, Shin Ae Ku, Ja Yoon Cho, Won Ki Shin, Chol Ho
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Allergy, Asthma & Clinical Immunology
BackgroundThe prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently undergone rapid changes, corresponding changes in the characteristics of AR patients have not been well documented. Therefore, we ai...
Labrosse, Roxane Paradis, Louis Samaan, Kathryn Lacombe-Barrios, Jonathan Paradis, Jean Bégin, Philippe Des Roches, Anne
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Allergy, Asthma & Clinical Immunology
Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicillin. However, the role of PST is increasingly questioned in the pediatric setting. To resolve the question of PST’s diagnostic accuracy, consec...
Jackson, Bradley Cleto, Erica Jeimy, Samira
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Allergy, Asthma & Clinical Immunology
Considering its recent legalization in Canada, the health implications of Cannabis sativa exposure, including allergy, are coming to the forefront of medical study and interest. C. sativa allergy is an issue that affects recreational users of the substance, processors, agricultural workers, and contacts of Cannabis aeroallergens and secondhand prod...
Pedini, Veronica Verga, Jacopo Umberto Terrenato, Irene Menghini, Denise Mezzanotte, Cristina Danieli, Maria Giovanna
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Allergy, Asthma & Clinical Immunology
BackgroundCommon variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency and has a broad spectrum of clinical manifestations. Among non-infectious complications, an increased incidence of malignancies may have a special relevance for survival, but little is known about treatment efficacy on malignant complications.M...
Polito, V. Barbacki, A. Isabwe, G.
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Allergy, Asthma & Clinical Immunology
BackgroundWhile drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.Case presentationWe describe a case of a 58-year-old female patient who received rituximab for the first time for treatment of rheumatoid arthritis. She developed sy...
Mümmler, Carlo Kemmerich, Bernd Behr, Jürgen Kneidinger, Nikolaus Milger, Katrin
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Allergy, Asthma & Clinical Immunology
BackgroundAllergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction to aspergillus species colonizing the airways of patients with asthma or cystic fibrosis. Biologics including anti-IgE and anti-IL5 antibodies have strongly changed the treatment of severe asthmatics and have partly been reported to be effective in the tr...
