Veličković, Vladica M Spelman, Tim Clark, Michael Probst, Sebastian Armstrong, David G Steyerberg, Ewout
Published in
Advances in wound care
Significance: Chronic wounds are associated with significant morbidity, marked loss of quality of life, and considerable economic burden. Evidence-based risk prediction to guide improved wound prevention and treatment is limited by the complexity in their etiology, clinical underreporting, and a lack of studies using large high-quality datasets. Re...
Huerta, Carlos Theodore Ortiz, Yulexi Y Liu, Zhao-Jun Velazquez, Omaida C
Published in
Advances in wound care
Significance: Given their capacity for self-renewal, multilineage differentiation, and immunomodulatory potential, mesenchymal stem cells (MSCs) represent a promising modality of clinical therapy for both regenerative medicine and immune diseases. In this study, we review the key approaches and popular methods utilized to boost potency and modify f...
Tran, Huy Quang Shahriar, S M Shatil Yan, Zheng Xie, Jingwei
Published in
Advances in wound care
Significance: Nowadays, the wound dressing is no longer limited to its primary wound protection ability. Hydrogel, sponge-like material, three dimensional-printed mesh, and nanofiber-based dressings with incorporation of functional components, such as nanomaterials, growth factors, enzymes, antimicrobial agents, and electronics, are able to not onl...
Kang, Hwan June Kumar, Suneel Dash, Biraja C Hsia, Henry C Yarmush, Martin L Berthiaume, François
Published in
Advances in wound care
Objective: Chronic skin wounds are one of the most devastating complications in diabetic patients due to the formation of advanced glycation end-products (AGEs) resulting from nonenzymatic glycation of proteins and lipids in hyperglycemia. AGEs, upon binding their receptors (RAGEs), trigger proinflammatory signals that impair wound healing in diabe...
Matar, Dany Y Ng, Brian Darwish, Oliver Wu, Mengfan Orgill, Dennis P Panayi, Adriana C
Published in
Advances in wound care
Significance: The skin is the crucial first-line barrier against foreign pathogens. Compromise of this barrier presents in the context of inflammatory skin conditions and in chronic wounds. Skin conditions arising from dysfunctional inflammatory pathways severely compromise the quality of life of patients and have a high economic impact on the U.S....
Bernatchez, Stéphanie F Bichel, Jens
Published in
Advances in wound care
Significance: Healthy skin provides a barrier to contaminants. Breaches in skin integrity are often encountered in the patient health care journey, owing to intrinsic health issues or to various procedures and medical devices used. The time has come to move clinical practice beyond mere awareness of medical adhesive-related skin injury and toward i...
DaVanzo, Joan Hartzman, Alex Surfield, Christopher Dobson, Allen
Published in
Advances in wound care
Objective: To compare outcomes for Medicare patients with diabetic foot ulcer(s) (DFU) receiving cryopreserved placental membrane containing viable cells (vCPM) to other Cellular- and Tissue-Based Products (CTPs). Approach: Patients with DFU and CTP use were selected in Medicare claims (2013-2017) by using a strict definition of DFU with demonstrat...
Carter, Marissa J Frykberg, Robert G Oropallo, Alisha Sen, Chandan K Armstrong, David G Nair, Harikrishna K R Serena, Thomas E
Published in
Advances in wound care
Objective: To conduct a systematic review and meta-analysis of recently published randomized controlled trials (RCTs) that employed the use of topical oxygen therapy (TOT) as an adjunct therapy in the treatment of Wagner 1 and 2 diabetic foot ulcers. Approach: Following a literature search of eligible studies from 2010 onward, four RCTs were includ...
Chiu, Alvis Sharma, Dhavan Zhao, Feng
Published in
Advances in wound care
Significance: Diabetic foot ulcers (DFU) are a mounting problem with the increasingly frail population. Injuries that would otherwise heal are kept open by risk factors such as diabetes, obesity, and age-related conditions, which interferes with the natural wound healing processes. Recent Advances: This review summarizes recent advancements in the ...
Parker, Jennifer B Griffin, Michelle F Spielman, Amanda F Wan, Derrick C Longaker, Michael T
Published in
Advances in wound care
Significance: Foreign body response (FBR), wherein a fibrotic capsule forms around an implanted structure, is a common surgical complication that often leads to pain, discomfort, and eventual revision surgeries. Although believed to have some mechanistic overlap with normal wound healing, much remains to be discovered about the specific mechanism b...