Skogvall, S Grampp, W
Published in
Acta physiologica Scandinavica
The spontaneous tone in isolated six-segment preparations of guinea-pig trachea was examined. In 12% oxygen (corresponding to normal systemic arterial oxygen pressure) the preparations developed a spontaneous tone with regular oscillations (6.6 min(-1)), usually grouped in so-called complexes (7.5 h(-1)). The average tone during an entire complex a...
Yasuda, T Inashima, S Sasaki, S Kikuchi, K Niihata, S Wada, M Katsuta, S
Published in
Acta physiologica Scandinavica
This study examined the effects of acute high-intensity and moderate-intensity exercise on Ca2+-stimulated adenosine triphosphatase (ATPase) activity and the Ca2+ and ATP dependence of Ca2+-ATPase of the sarcoplasmic reticulum (SR) in the soleus muscle. The rats were run on 10% grade at 50 m min(-1) or 25 m min(-1) until fatigued (avg. time to exha...
Guron, G Nilsson, A Nitescu, N Nielsen, S Sundelin, B Frøkiaer, J Friberg, P
Published in
Acta physiologica Scandinavica
Neonatal angiotensin-converting enzyme inhibition or angiotensin II type-1 receptor blockade induces irreversible renal histological abnormalities and an impaired urinary concentrating ability in the rat. The aim of the present study was to determine the pathophysiological mechanisms underlying the defect in urine concentration in adult rats treate...
Arheden, H Hellstrand, P Wohlfart, B
Published in
Acta physiologica Scandinavica
Thin trabeculae were dissected from the right ventricle of guinea-pig heart and stimulated to contract isometrically at 0.5 Hz (26 degrees C). Rapid and transient changes of force were obtained by inducing three extra systoles (ES1-3) at 450-ms intervals. The two regular contractions (P1-2) following (ES1-3) were potentiated. Fura-2 salt was microi...
Borthne, K Langslet, A Lindberg, H Osnes, J B Skomedal, T
Published in
Acta physiologica Scandinavica
To analyse the possible influence of endogenous muscarinic activity on the inotropic effects of endogenously released noradrenaline in field stimulated myocardial preparations from atria of children with congenital heart defects, we studied the maximal effect of the muscarinic antagonist atropine (1.5 micromol L(-1)). Maximal force of contraction i...
Bergdahl, A Valdemarsson, S Nilsson, T Sun, X Y Hedner, T Edvinsson, L
Published in
Acta physiologica Scandinavica
It was examined to what extent congestive heart failure (CHF) in rats, induced by ligation of the left coronary artery, affects the vascular responses to the vasodilatory substances acetylcholine (ACh), calcitonin gene-related peptide (CGRP), and substance P (SP). After induction of CHF status, the basilar, mesenteric and renal arteries and the ili...
Uusimaa, P Huttunen, K Ruskoaho, H Linnaluoto, M Ikäheimo, M
Published in
Acta physiologica Scandinavica
The effect of volume reduction on vasoactive substances and their role in estimating dry weight in haemodialysis patients was studied. Plasma atrial natriuretic peptide (ANP), catecholamines, antidiuretic hormone, renin activity and serum aldosterone were measured in 12 patients before and after bicarbonate haemodialysis. Haemodynamical changes wer...
Johansson, B L Pernow, J
Published in
Acta physiologica Scandinavica
Recent findings suggest that proinsulin C-peptide improves renal and nerve function as well as microcirculation in patients with insulin-dependent diabetes possibly by stimulating Na-K+-ATPase activity. Furthermore, in vitro studies on proximal rat renal tubule cells show that the effect of C-peptide on Na+, K+-ATPase activity is potentiated in the...
Somlyo, A P Somlyo, A V
Published in
Acta physiologica Scandinavica
A brief summary of recent studies of pharmacomechanical coupling is presented, with emphasis on the role of GTP-binding proteins and Ca(2+)-independent regulation of contraction (Ca(2+)-sensitization/desensitization) through regulatory myosin light chain (MLC20) phosphorylation and dephosphorylation. Pharmacomechanical regulation of cytosolic [Ca2+...
Marston, S Burton, D Copeland, O Fraser, I Gao, Y Hodgkinson, J Huber, P Levine, B el-Mezgueldi, M Notarianni, G
...
Published in
Acta physiologica Scandinavica
The basic structure and functional properties of smooth muscle thin filaments were established about 10 years ago. Since then we and others have been working on the details of how tropomyosin, caldesmon and the Ca(2+)-binding protein regulate actin interaction with myosin. Our work has tended to emphasize the similarities between caldesmon and trop...
