The combination of four cell-cycle regulators: a new direction for inducing adult cardiomyocyte proliferation
Published in Acta Biochimica et Biophysica Sinica
TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer
Published in Acta Biochimica et Biophysica Sinica
Gastric cancer is one of the most common cancers worldwide and is the third leading cause of cancer-related deaths globally. Although significant progress has been made in the diagnosis and treatment for the cancer, less improvement has been made in overall survival rate. Thus, there is an urgent need for a better understanding of the biological as...
Differential localizations of protein phosphatase 1 isoforms determine their physiological function in the heart
Published in Acta Biochimica et Biophysica Sinica
Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both primary cell culture and knockout mice to investigate the isoform-specific roles of PP1s in the heart. In both neonatal and adult cardiac myocytes, PP1β was mai...
Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer.
Published in Acta biochimica et biophysica Sinica
The TGFβ superfamily in cardiac dysfunction
Published in Acta Biochimica et Biophysica Sinica
TGFβ superfamily includes the transforming growth factor βs (TGFβs), bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and Activin/Inhibin families of ligands. Among the 33 members of TGFβ superfamily ligands, many act on multiple types of cells within the heart, including cardiomyocytes, cardiac fibroblasts/myofibroblas...
Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical r...
...Published in Acta biochimica et biophysica Sinica
Serum carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is dysregulated in various malignant tumors and has been associated with tumor progression. However, the expression and regulatory mechanisms of serum CEACAM1 in gastrointestinal cancer are still unclear. The expression ratio of the CEACAM1-L and CEACAM1-S isoforms has seldom...
Direct non transcriptional role of NF-Y in DNA replication
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Published in Acta Biochimica et Biophysica Sinica
NF-Y is a heterotrimeric transcription factor, which plays a pioneer role in the transcriptional control of promoters containing the CCAAT-box, among which genes involved in cell cycle regulation, apoptosis and DNA damage response. The knock-down of the sequence-specific subunit NF-YA triggers defects in S-phase progression, which lead to apoptotic...
Regulation of cellular innate antiviral signaling by ubiquitin modification.
Published in Acta biochimica et biophysica Sinica
Host pattern-recognition receptors (PRRs) recognize pathogen-associated molecular patterns generated by invading viruses and initiate a series of signaling cascades that lead to the activation of interferon-regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) and subsequent induction of type I interferons (IFNs). Posttranslational modification ...
Bcl-2-associated transcription factor 1 interacts with fragile X-related protein 1.
Published in Acta biochimica et biophysica Sinica
The absence of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), which is the leading cause of hereditary mental retardation. Fragile X-related protein 1 (FXR1P), which plays an important role in normal muscle development, is one of the two autosomal paralogs of FMRP. To understand the functions of FXR1P, we screened FXR1...
Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors.
Published in Acta biochimica et biophysica Sinica
Foreign nucleic acids, the essential signature molecules of invading pathogens that act as danger signals for host cells, are detected by endosomal nucleic acid-sensing toll-like receptors (TLRs) 3, 7, 8, 9, and 13. These TLRs have evolved to recognize 'non-self' nucleic acids within endosomal compartments and rapidly initiate innate immune respons...
