Ayu Dewi Ni Nyoman Carsten G. K. Lüder
Published in
APOPTOSIS
in Jun 01, 2013
Ancient pathways of an apoptosis-like cell death have been identified in unicellular eukaryotes including protozoan parasites. Here, we examined programmed cell death in the apicomplexan Toxoplasma gondii which is a common intracellular pathogen of humans and warm-blooded animals. Treatment of extracellular T. gondii with various pro-apoptotic stim...
Patrick Y. Kim Aldwin Suryo Rahmanto Owen Tan Murray D. Norris Michelle Haber Glenn M. Marshall Belamy B. Cheung
Published in
APOPTOSIS
in Feb 13, 2013
TRIM16 exhibits tumour suppressor functions by interacting with cytoplasmic vimentin and nuclear E2F1 proteins in neuroblastoma and squamous cell carcinoma cells, reducing cell migration and replication. Reduced TRIM16 expression in a range of human primary malignant tissues correlates with increased malignant potential. TRIM16 also induces apoptos...
Alessandra Rossi Janet M. Lord
Published in
APOPTOSIS
in Jan 01, 2013
Neutrophils are abundant, short-lived leukocytes that play a key role in the immune defense against microbial infections. These cells die by apoptosis following activation and uptake of microbes and will also enter apoptosis spontaneously at the end of their lifespan if they do not encounter a pathogen. Adiponectin exerts anti-inflammatory effects ...
Felix M. Wensveen Christian R. Geest Sten F. W. M. Libregts Ingrid A. M. Derks Paul G. Ekert Verena Labi Andreas Villunger Martijn A. Nolte Eric Eldering
Published in
APOPTOSIS
in Jan 01, 2013
Apoptosis plays an essential role in the control of erythropoiesis under normal and pathological conditions. However, the contribution of individual proteins within cell death signalling pathways remains poorly defined. Here, we investigated the role of the pro-apoptotic Bcl-2 family member Noxa in the regulation of erythropoiesis. We found that ex...
Masayoshi Yamaguchi
Published in
APOPTOSIS
in Jan 01, 2013
Regucalcin (RGN/SMP30) was originally discovered in 1978 as a calcium-binding protein that does not contain the EF-hand motif of as a calcium-binding domain. The name, regucalcin, was proposed for this calcium-binding protein, which can regulate various Ca2+-dependent enzymes activation in liver cells. The regucalcin gene is localized on the X chro...
Kai Hung Tiong Li Yen Mah Chee-Onn Leong
Published in
APOPTOSIS
in Jan 01, 2013
The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair. Over the past decades, numerous pathological conditions and developmental syndromes have emerged as a consequence of deregulation in the FGFRs signaling network. This review ai...
Indrajit Chowdhury Winston E. Thompson Crystal Welch Kelwyn Thomas Roland Matthews
Published in
APOPTOSIS
in Jan 01, 2013
Mammalian ovarian follicular development is tightly regulated by crosstalk between cell death and survival signals, which include both endocrine and intra-ovarian regulators. Whether the follicle ultimately ovulates or undergoes atresia is dependent on the expression and actions of factors promoting follicular cell proliferation, differentiation or...
Cristina Bardita Dan Predescu Matthew J. Justice Irina Petrache Sanda Predescu
Published in
APOPTOSIS
in Jul 10, 2012
Intersectin-1s (ITSN-1s) is a general endocytic protein involved in regulating lung vascular permeability and endothelial cells (ECs) survival, via MEK/Erk1/2MAPK signaling. To investigate the in vivo effects of ITSN-1s deficiency and the resulting ECs apoptosis on pulmonary vasculature and lung homeostasis, we used an ITSN-1s knocked-down (KDITSN)...
Marco Beauséjour Dominique Noël Sonya Thibodeau Véronique Bouchard Charlène Harnois Jean-François Beaulieu Marie-Josée Demers Pierre H. Vachon
Published in
APOPTOSIS
in Jun 01, 2012
In human intestinal epithelial crypt (HIEC) cells, the PI3-K/Akt-1 pathway is crucial for the promotion of cell survival and suppression of anoikis. Class I PI3-K consists of a complex formed by a catalytic (C) and regulatory (R) subunit. Three R (p85α, β, and p55γ) and four C (p110α, β, γ and δ) isoforms are known. Herein, we analyzed the e...
Kristel Kemper Hans Rodermond Selçuk Colak Catarina Grandela Jan Paul Medema
Published in
APOPTOSIS
in May 01, 2012
Colorectal cancer stem cells (CSCs) drive tumor growth and are suggested to initiate distant metastases. Moreover, colon CSCs are reportedly more resistant to conventional chemotherapy, which is in part due to upregulation of anti-apoptotic Bcl-2 family members. To determine whether we could circumvent this apoptotic blockade, we made use of an ind...