Turk, Gabriela Gundlach, Swantje Carobene, Mauricio Schindler, Michael Salomon, Horacio Philippe Benaroch
Published in
AIDS Research and Human Retroviruses
HIV-1 Nef protein plays a major role in viral immunopathogenesis, modulating surface expression of several immune receptors, altering signal transduction pathways, and enhancing viral infectivity, among other activities. Nef also exhibits great intersubtype diversity, but most studies have been focused only on Nef proteins from subtype B. Thus, lit...
Yuan, Wen Li, Xing Kasterka, Marta Gorny, Miroslaw K Zolla-Pazner, Susan Sodroski, Joseph
Published in
AIDS research and human retroviruses
Trimerization of the human immunodeficiency virus (HIV-1) envelope glycoproteins is mediated by the ectodomain of the gp41 transmembrane glycoprotein. Here we investigate oligomer-specific conformations of gp41 by using monoclonal antibodies (MAbs) from HIV-1-infected humans. Human MAbs directed against the cluster I region of gp41 recognized trime...
Lynch, Rebecca M Shen, Tongye Gnanakaran, S Derdeyn, Cynthia A
Published in
AIDS research and human retroviruses
Human immunodeficiency virus type 1 (HIV-1) group M is responsible for the current AIDS pandemic and exhibits exceedingly high levels of viral genetic diversity around the world, necessitating categorization of viruses into distinct lineages, or subtypes. These subtypes can differ by around 35% in the envelope (Env) glycoproteins of the virus, whic...
Samikkannu, Thangavel Saiyed, Zainulabedin M Rao, K V K Babu, Dakshayani Kadiyala Rodriguez, Jose W Papuashvili, Marina N Nair, Madhavan P N
Published in
AIDS research and human retroviruses
Previous studies have demonstrated that infection with HIV-1 clades might differentially contribute to the neuropathogenesis of HIV-1-associated dementia (HAD). HIV-1 transactivator regulatory protein (Tat) plays a major role in the process of disruption of neuronal function. It is not well understood how these HIV-1 subtypes exert different neurop...
Basu, Jayasri Romney, Seymour L Angeletti, Ruth H Vermund, Sten H Nieves, Edward Kadish, Anna S Mikhail, Magdy S Orr, George A
Published in
AIDS research and human retroviruses
While investigating whether proteins retrieved by cervicovaginal lavages (CVL) from women with cervical intraepithelial neoplasia (CIN) might correlate with risk of progression to invasive cervical cancer, we unexpectedly identified HIV gag and env glycoprotein in CVL from women with HIV-negative serology. HIV antigens were consistently identified ...
Eshleman, Susan H Hudelson, Sarah E Smith, Peter Hackett, John Holzmayer, Vera Swanson, Priscilla Devare, Sushil G Marlowe, Natalia
Published in
AIDS research and human retroviruses
A prototype assay was used to genotype integrase (IN) from 120 HIV-1- infected IN inhibitor-naive adults from Argentina, Brazil, Cameroon, South Africa, Thailand, and Uganda. Subtype designations based on analysis of pol IN sequences were A (14), B (15), C (12), D (11), F (12), G (7), H (1), CRF01_AE (9), CRF02_AG (34), CRF22_01A1 (4), and CRF37_cp...
Cao, Weiwei Jamieson, Beth D. Hultin, Lance E. Hultin, Patricia M. Detels, Roger
Published in
AIDS Research and Human Retroviruses
Regulatory T cells (Tregs) may play an important role in the immunopathology of chronic HIV-1 infection due to their potent suppressive activity of both T cell activation and effector function. To investigate the correlation between Tregs and immune activation during untreated chronic HIV-1 infection, we conducted a nested case–control study within...
Canaday, David H Wu, Mianda Lu, Shigou Aung, Htin Peters, Pierre Baseke, Joy Mackay, Wilma Mayanja-Kizza, Harriet Toossi, Zahra
Published in
AIDS research and human retroviruses
An in vitro mononuclear cell system to model the microenvironment of coinfection with HIV-1 and Mycobacterium tuberculosis (MTB) was developed. This cellular system was used to assess the interaction of MTB-infected monocytes and T cells from dually infected HIV-1/TB patients with pulmonary tuberculosis (TB). Subjects with higher induction of HIV-1...
Archin, Nancie M Espeseth, Amy Parker, Daniel Cheema, Manzoor Hazuda, Daria Margolis, David M
Published in
AIDS research and human retroviruses
Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ability of the potent inhibitor recently licensed for use in oncology, suberoylanilide hydrox...
Mujugira, Andrew Wester, C William Kim, Soyeon Bussmann, Hermann Gaolathe, Tendani
Published in
AIDS research and human retroviruses
The response to highly active antiretroviral treatment (HAART) and predictors of mortality among patients with advanced HIV infection (CD4(+) cell count
