Rudy, Bret J Sleasman, John Kapogiannis, Bill Wilson, Craig M Bethel, James Serchuck, Leslie Ahmad, Sushma Cunningham, Coleen K
Published in
AIDS research and human retroviruses
This was a proof-of-principle study to evaluate the impact of short cycle therapy (SCT; 4 days on/3 days off) in adolescents and young adults with good viral suppression on a protease inhibitor-based antiretroviral regimen. Subjects were recruited by the Adolescent Trials Network for HIV/AIDS Interventions and the Pediatric AIDS Clinical Trials Gro...
Reeve, Aaron B Patel, Kalpana Pearce, Nicholas C Augustus, Katherine V Domingues, Heber G O'Neil, Shawn P Novembre, Francis J
Published in
AIDS research and human retroviruses
The simian lentivirus strain SIVsmmFGb is a viral swarm population inducing neuropathology in over 90% of infected pigtailed macaques and serves as a reliable model for HIV neuropathogenesis. However, little is understood about the genetic diversity of this virus, how said diversity influences the initial seeding of the central nervous system and l...
Rivera-Amill, Vanessa Noel, Richard J Jr Román, Ivelisse Rivera Flores, Yashira García Buch, Shilpa Kumar, Anil
Published in
AIDS research and human retroviruses
Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent group along with that in the con...
Jordan, Parris S Poon, Art Eron, Joseph Squires, Kathleen Ignacio, Caroline Richman, Douglas D Smith, Davey M
Published in
AIDS research and human retroviruses
A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. A one codon insert was observed in the protease region between codon 40 and 41 simultaneously with a two codon insert present in the reverse transcriptase region at codon 69.
Mansoor, Ather Golub, Elizabeth T Dehovitz, Jack Anastos, Kathryn Kaplan, Robert C Lazar, Jason M
Published in
AIDS research and human retroviruses
Left ventricular hypertrophy (LVH) is an independent predictor of major cardiovascular events. Cardiovascular risk is increased among human immunodeficiency virus (HIV)-infected patients. To assess LV mass/hypertrophy in HIV infection, 654 women enrolled in the Women's Interagency HIV Study underwent transthoracic echocardiography. There were 454 H...
Yilmaz, Aylin Izadkhashti, Arash Price, Richard W Mallon, Patrick W De Meulder, Marc Timmerman, Philip Gisslén, Magnus
Published in
AIDS research and human retroviruses
Darunavir is the most recently licensed protease inhibitor currently used in treatment-experienced HIV-infected individuals. Our objective was to determine darunavir concentrations in cerebrospinal fluid (CSF) and plasma in subjects receiving antiretroviral treatment regimens containing ritonavir-boosted darunavir. Darunavir concentrations were det...
Cardozo, Timothy Swetnam, James Pinter, Abraham Krachmarov, Chavdar Nadas, Arthur Almond, David Zolla-Pazner, Susan
Published in
AIDS research and human retroviruses
Epitopes, also known as antigenic determinants, are small clusters of specific atoms within macromolecules that are recognized by the immune system. Such epitopes can be targeted with vaccines designed to protect against specific pathogens. The third variable loop (V3 loop) of the HIV-1 pathogen's gp120 surface envelope glycoprotein can be a highly...
Bärnighausen, Till Tanser, Frank Newell, Marie-Louise
Published in
AIDS research and human retroviruses
To understand the dynamics of the HIV epidemic and to plan HIV treatment and prevention programs, it is critical to know how HIV incidence in a population evolves over time. We used data from a large population-based longitudinal HIV surveillance in a rural community in South Africa to test whether HIV incidence in this population has changed in th...
Graham, Susan M Holte, Sarah Kimata, Jason T Wener, Mark H Overbaugh, Julie
Published in
AIDS research and human retroviruses
A decrease in circulating albumin levels after seroconversion has been reported as a predictor of disease progression in HIV-infected adults. We hypothesized that a similar decrease would be seen in pig-tailed macaques in early SIV infection, and that the degree of this decrease would be related to the pathogenicity of the infecting viral strain. T...
Turk, Gabriela Gundlach, Swantje Carobene, Mauricio Schindler, Michael Salomon, Horacio Philippe Benaroch
Published in
AIDS Research and Human Retroviruses
HIV-1 Nef protein plays a major role in viral immunopathogenesis, modulating surface expression of several immune receptors, altering signal transduction pathways, and enhancing viral infectivity, among other activities. Nef also exhibits great intersubtype diversity, but most studies have been focused only on Nef proteins from subtype B. Thus, lit...
