Carrión, A G Laguna-Torres, V A Soto-Castellares, G Castillo, M Salazar, E Negron, E Kolevic, L Montano, S M Sánchez, J L Bautista, C T
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AIDS research and human retroviruses
In Peru, there is a lack of information on molecular analysis in pediatric human immunodeficiency virus (HIV) infection. At present, the mother-to-child transmission rate is estimated at approximately 2-4%. The objective of this study was to assess the molecular epidemiology of HIV-1 in infected children. Children with suspected or confirmed pulmon...
Buonaguro, L Tornesello, M L Jewis, George K Buonaguro, F M
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AIDS research and human retroviruses
We have recently shown that HIV-1 Pr55gag virus-like particles (HIV-VLPs), produced in a baculovirus expression system and presenting a gp120 molecule from a Ugandan HIV-1 isolate of clade A (HIV-VLP(A)s), induce maturation and activation of antigen-presenting cells (APCs) in fresh peripheral blood mononuclear cells (PBMCs) from seronegative as wel...
Wang, Honghong Zhou, Jun He, Gouping Luo, Yang Li, Xianhong Yang, Aiyun Fennie, Kristopher Williams, Ann B
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AIDS research and human retroviruses
This study aimed to assess levels of ART adherence and to examine the relationship between adherence and treatment outcomes. A longitudinal study in Hunan and Hubei provinces used the CPCRA Antiretroviral Medication Self-Report and a 7-day Visual Analogue Scale to assess levels of adherence, while quality of life was evaluated using SF-36. CD4 cell...
Huang, Wei Toma, Jonathan Stawiski, Eric Fransen, Signe Wrin, Terri Parkin, Neil Whitcomb, Jeannette M Coakley, Eoin Hecht, Frederick M Deeks, Steven G
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Published in
AIDS research and human retroviruses
We screened 150 individuals from two recent seroconverter cohorts and found that six (4%) had CXCR4-using viruses. Clonal analysis of these six individuals, along with a seventh individual identified during clinical care as a recent seroconverter, revealed the presence of both X4- and dual-tropic variants in these recently infected adults. The abil...
Church, Jessica D Mwatha, Anthony Bagenda, Danstan Omer, Saad B Donnell, Deborah Musoke, Philippa Nakabiito, Clemensia Eure, Chineta Bakaki, Paul Matovu, Flavia
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AIDS research and human retroviruses
Use of single dose nevirapine (sdNVP) to prevent HIV mother-to-child transmission is associated with the emergence of NVP resistance in many infants who are HIV infected despite prophylaxis. We combined results from four clinical trials to analyze predictors of NVP resistance in sdNVP-exposed Ugandan infants. Samples were tested with the ViroSeq HI...
Church, Jessica D Huang, Wei Parkin, Neil Marlowe, Natalia Guay, Laura A Omer, Saad B Musoke, Philippa Jackson, J Brooks Eshleman, Susan H
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AIDS research and human retroviruses
Detailed comparisons of HIV drug resistance assays are needed to identify the most useful assays for research studies, and to facilitate comparison of results from studies that use different methods. We analyzed nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in 40 HIV-infected Ugandan infants who had received nevirapine (NVP)-base...
Gandhi, Nimisha Saiyed, Zainulabedin Thangavel, Samikkannu Rodriguez, Jose Rao, K V K Nair, Madhavan P N
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AIDS research and human retroviruses
The existence of multiple subtypes of HIV-1 worldwide has created new challenges to control HIV-1 infection and associated neuropathogenesis. Previous studies indicate a difference in neuropathogenic manifestations of HIV-1-associated neuroAIDS between clade B- and clade C-infected subjects with clade B being more neuropathogenic than clade C. Howe...
Sahbandar, Ivo N Takahashi, Kiyomi Djoerban, Zubairi Firmansyah, Iman Naganawa, Satoshi Motomura, Kazushi Sato, Hironori Kitamura, Katsuhiko Pohan, Herdiman T Sato, Shigehiro
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Published in
AIDS research and human retroviruses
HIV infection is a major problem in Indonesia. The number of people living with HIV has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles of HIV/AIDS in Indonesia, a cross-sectional study involving 208 HIV-1-seropositive individuals was conducted...
Hudelson, Sarah E Marlowe, Natalia Huang, Wei Bruce, Robert Church, Jessica D Husnik, Marla Donnell, Deborah Coates, Thomas Jackson, J Brooks Chesney, Margaret
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AIDS research and human retroviruses
We analyzed HIV gp41 from 195 men in the United States who were HIV-1 infected between 1999 and 2002, before enfuvirtide (ENF) was approved for clinical use in the United States. gp41 genotyping results were obtained for 175 samples. None of the samples had major ENF resistance mutations. Six (3.4%) samples had minor ENF resistance mutations in the...
Loo, Christopher P Long, Brian R Hecht, Frederick M Nixon, Douglas F Michaëlsson, Jakob
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AIDS research and human retroviruses
Natural killer (NK) cells can directly recognize virus-infected cells. Here, we demonstrate that NK cells also produce interferon (IFN)-gamma in an HIV-1-specific, T cell-dependent manner. After stimulation of peripheral blood mononuclear cells (PBMCs) from HIV-1-infected individuals with HIV-1-derived peptides, up to half of the IFN-gamma-producin...
