Israel, Liron L Braubach, Oliver Galstyan, Anna Chiechi, Antonella Shatalova, Ekaterina S Grodzinski, Zachary Ding, Hui Black, Keith L Ljubimova, Julia Y Holler, Eggehard
...
Published in
ACS nano
One of the major problems facing the treatment of neurological disorders is the poor delivery of therapeutic agents into the brain. Our goal is to develop a multifunctional and biodegradable nanodrug delivery system that crosses the blood-brain barrier (BBB) to access brain tissues affected by neurological disease. In this study, we synthesized a b...
Agarwal, Kriti Dai, Chunhui Joung, Daeha Cho, Jeong-Hyun
Published in
ACS nano
The limited spatial coverage of the plasmon enhanced near-field in 2D graphene ribbons presents a major hurdle in practical applications. In this study, diverse self-assembled 3D graphene architectures are explored that induce hybridized plasmon modes by simultaneous in-plane and out-of-plane coupling to overcome the limited coverage in 2D ribbons....
Guo, Ling Zhang, Ye Yang, Zeping Peng, Hui Wei, Runxiu Wang, Cuifeng Feng, Min
Published in
ACS nano
It is extremely difficult for cancer chemotherapy to control the peritoneal metastasis of advanced ovarian carcinoma given its inability to target disseminated tumors and the severe toxic side effects on healthy organs. Here, we report antitumor M1 macrophages developed as live-cell carriers that deliver anticancer drugs for the treatment of the me...
Long, Mingsheng Wang, Yang Wang, Peng Zhou, Xiaohao Xia, Hui Luo, Chen Huang, Shenyang Zhang, Guowei Yan, Hugen Fan, Zhiyong
...
Published in
ACS nano
A long-wavelength infrared photodetector based on two-dimensional materials working at room temperature would have wide applications in many aspects in remote sensing, thermal imaging, biomedical optics, and medical imaging. However, sub-bandgap light detection in graphene and black phosphorus has been a long-standing scientific challenge because o...
Verbeke, Rein Lentacker, Ine Breckpot, Karine Janssens, Jonas Van Calenbergh, Serge De Smedt, Stefaan C Dewitte, Heleen
Published in
ACS nano
Messenger RNA encoding tumor antigens has the potential to evoke effective antitumor immunity. This study reports on a nanoparticle platform, named mRNA Galsomes, that successfully co-delivers nucleoside-modified antigen-encoding mRNA and the glycolipid antigen and immunopotentiator α-galactosylceramide (α-GC) to antigen-presenting cells after intr...
Bačová, Petra Glynos, Emmanouil Anastasiadis, Spiros H Harmandaris, Vagelis
Published in
ACS nano
Heterogeneous polymer-based nanoparticles comprise a very promising family of materials for a broad range of applications. Here, we present a detailed study of structural heterogeneities in nanostructured single-molecule nanoparticles in various environments by means of atomistic molecular dynamics simulations. The nanoparticles consist of mikto-ar...
Lin, Qiaoya Deng, Deqiang Song, Xianlin Dai, Bolei Yang, Xiaoquan Luo, Qingming Zhang, Zhihong
Published in
ACS nano
Kupffer cells (KCs), potent scavenger cells located in hepatic sinusoids, constantly phagocytize and degrade foreign materials to maintain metabolism and clearance. Understanding the strategic KC arrangement which links to their spatial location and function in hepatic lobules, the basic functional unit in the liver, is highly valuable for characte...
Yu, Wuyang Liu, Tao Zhang, Mingkang Wang, Zixu Ye, Jingjie Li, Chu-Xin Liu, Wenlong Li, Runqing Feng, Jun Zhang, Xian-Zheng
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Published in
ACS nano
Hypoxia, a ubiquitously aberrant phenomenon implicated in tumor growth, causes severe tumor resistance to therapeutic interventions. Instead of the currently prevalent solution through intratumoral oxygen supply, we put forward an "O2-economizer" concept by inhibiting the O2 consumption of cell respiration to spare endogenous O2 and overcome the hy...
Zhou, Minfeng Hou, Ting Li, Jinxing Yu, Shanshan Xu, Zijian Yin, Miao Wang, Joseph Wang, Xiaolei
Published in
ACS nano
For many medical treatments, particularly cancer, it is necessary to develop a biocompatible microscale device that can carry a sufficient amount of a drug and deliver it to target sites. While chemically powered micromotors have been applied in live animal therapy, many of them are difficult to biodegrade in vivo, which might cause toxicity and si...
Christensen, Dennis Bøllehuus Hansen, Lasse Leboux, Romain Jiskoot, Wim Christensen, Jan Pravsgaard Andersen, Peter Dietrich, Jes
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ACS nano
Worldwide, enteric infections rank third among all causes of disease burdens, and vaccines able to induce a strong and long-lasting intestinal immune responses are needed. Parenteral immunization generally do not generate intestinal IgA. Recently, however, injections of retinoic acid (RA) dissolved in oil, administered multiple times before vaccina...
