Published in ACS nano
The programmed crystallization of particles into low-symmetry lattices represents a major synthetic challenge in the field of colloidal crystal engineering. Herein, we report an approach to realizing such structures that relies on a library of low-symmetry Au nanoparticles, with synthetically adjustable dimensions and tunable aspect ratios. When mo...
Published in ACS nano
Desmoplastic tumors are normally resistant to nanoparticle-based chemotherapy due to dense stroma and limited particle permeability inside the tumor. Herein, we reported that hydralazine (HDZ)-an antihypertension vasodilator-would dramatically promote nanoparticle penetration in advanced desmoplastic tumors. First, a HDZ-liposome system was develop...
Published in ACS nano
The eukaryotic cell compartmentalizes into spatially confined, membrane-enclosed, intracellular structures ( e. g., organelles, endosomes, and vesicles). Here, peculiar physicochemical properties of the local environment occur and participate in the regulation of ongoing molecular processes. In spite of the huge amount of available environmental pr...
Published in ACS nano
Various types of biological and synthetic nanopores have been developed and utilized for the high-throughput investigation of individual biomolecules. Biological nanopores made with channel proteins are so far superior to solid-state ones in terms of sensitivity and reproducibility. However, the performance of a biological nanopore is dependent on ...
Published in ACS nano
The extracellular environment is a complex medium in which cells secrete and consume metabolites. Molecular gradients are thereby created near cells, triggering various biological and physiological responses. However, investigating these molecular gradients remains challenging because the current tools are ill-suited and provide poor temporal and s...
Published in ACS nano
Inspired by cocktails, we designed a medium term (2-20 weeks) male contraceptive strategy. Through a sequential injection process of four reagents (calcium alginate hydrogel, PEG-Au nanoparticles (PEG-AuNps), EDTA, and PEG-AuNps), physical clogging of the vas deferens and chemical inhibition of the sperm motility were realized simultaneously. The c...
Published in ACS nano
Laser-induced graphene (LIG) is a platform material for numerous applications. Despite its ease in synthesis, LIG's potential for use in some applications is limited by its robustness on substrates. Here, using a simple infiltration method, we develop LIG composites (LIGCs) with physical properties that are engineered on various substrate materials...
Published in ACS nano
In contrast to small-molar-mass compounds, detailed structural investigations of inorganic core-organic ligand shell hybrid nanoparticles remain challenging. The assessment of batch-reaction-induced heterogeneities of surface chemical properties and their correlation with particle size has been a particularly long-standing issue. Applying a combina...
Published in ACS nano
Combination therapy, especially photodynamic/photothermal therapy (PDT/PTT), has shown promising applications in cancer therapy. However, sequential irradiation by two different laser sources and even the utilization of single high-power laser to induce either combined PDT/PTT or individual PTT will be subjected to prolonged treatment time, complic...
Published in ACS nano
Collective cell migration plays a pivotal role in development, wound healing, and metastasis, but little is known about the mechanisms and coordination of cell migration in 3D microenvironments. Here, we demonstrate a 3D wound healing assay by photothermal ablation for investigating collective cell migration in epithelial tissue structures. The nan...
