Shen, Weilu Kalies, Stefan Madrid, Marinna Heisterkamp, Alexander Mazur, Eric
Published in
ACS biomaterials science & engineering
There is a great need in the biomedical field to efficiently, and cost-effectively, deliver membrane-impermeable molecules into the cellular cytoplasm. However, the cell membrane is a selectively permeable barrier, and large molecules often cannot pass through the phospholipid bilayer. We show that nanosecond laser-activated polymer surfaces of com...
Yu, Justine R Varrey, Pranav Liang, Barry J Huang, Huang-Chiao Fisher, John P
Published in
ACS biomaterials science & engineering
Skin regeneration in chronic wounds is often delayed due to persistent inflammation induced by underlying conditions such as diabetes. This effect is mediated, in part, by macrophages present in the wound, which can be stimulated to adopt either pro- or anti-inflammatory phenotypes depending on the status of the local microenvironment. In this work...
Zhao, Gaoqian Li, Jiaxin Fangfang Lv, Wang, Xiaochun Dong, Qing Liu, Dandan Zhang, Jinchao Li, Zhenhua Zhou, Xiaohan Liu, Huifang
...
Published in
ACS biomaterials science & engineering
Photothermal therapy (PTT) using nanoparticles is one of the research hotspots in the field of cancer therapy. However, the thermal resistance of tumor cells and the elimination of nanoparticles by the body's immune system reduce their therapeutic effect. Therefore, it is essential to reduce heat resistance, improve their biocompatibility, and redu...
Chen, Xiang Yu, Haojie Wang, Li Shen, Di Li, Chengjiang Zhou, Weibin
Published in
ACS biomaterials science & engineering
To simplify the preparation process of a glucose-responsive microneedle patch, a cross-linking-density changeable microneedle patch was designed. The microneedle patch was made up of a hydrogel formed by phenylboronic acid-grafted polyallylamine and poly(vinyl alcohol) (PVA). The gel was cross-linked by boronate ester bonds between phenylboronic ac...
Najafi Sani, Hassan Abrinia, Karen Haghighipour, Nooshin George, Daniel Remond, Yves Baniassadi, Majid
Published in
ACS biomaterials science & engineering
Not very far away, "tissue engineering" will become one of the most important branches of medical science for curing many types of diseases. This branch needs the cooperation of a wide range of sciences like medicine, chemistry, cellular biology, and genetic and mechanical engineering. Different parameters affect the final produced tissue, but the ...
Ender, Adriana Maria Kaygisiz, Kübra Räder, Hans-Joachim Mayer, Franz J Synatschke, Christopher V Weil, Tanja
Published in
ACS biomaterials science & engineering
Gradients of bioactive molecules play a crucial role in various biological processes like vascularization, tissue regeneration, or cell migration. To study these complex biological systems, it is necessary to control the concentration of bioactive molecules on their substrates. Here, we created a photochemical strategy to generate gradients using a...
Sun, Jie Xue, Pengpeng Liu, Jiayi Huang, Lantian Lin, Gaolong Ran, Kunjie Yang, Jiaojiao Lu, Cuitao Zhao, Ying-Zheng Xu, He-Lin
...
Published in
ACS biomaterials science & engineering
KPV (Lys-Pro-Val), which is a tripeptide derived from α-MSH (α-melanocyte-stimulating hormone), has an anti-inflammatory effect on colitis. However, KPV solution is very unstable when rectally administered, compromising its therapeutic efficacy. Herein, cysteamine-grafted γ-polyglutamic acid (SH-PGA) was synthesized by conjugating cysteamine with t...
Montoya, Carolina Kurylec, Julia Baraniya, Divyashri Tripathi, Aparna Puri, Sumant Orrego, Santiago
Published in
ACS biomaterials science & engineering
Ditte, Kristina Nguyen Le, Trang Anh Ditzer, Oliver Sandoval Bojorquez, Diana Isabel Chae, Soosang Bachmann, Michael Baraban, Larysa Lissel, Franziska
Published in
ACS biomaterials science & engineering
In the midst of the COVID-19 pandemic, adaptive solutions are needed to allow us to make fast decisions and take effective sanitation measures, e.g., the fast screening of large groups (employees, passengers, pupils, etc.). Although being reliable, most of the existing SARS-CoV-2 detection methods cannot be integrated into garments to be used on de...
Garcia Garcia, Cristobal Patkar, Sai S Jovic, Nina Mittal, Jeetain Kiick, Kristi L
Published in
ACS biomaterials science & engineering
Heterogeneities in hydrogel scaffolds are known to impact the performance of cells in cell-laden materials constructs, and we have employed the phase separation of resilin-like polypeptides (RLPs) as a means to generate such materials. Here, we study the compositional features of resilin-like polypeptides (RLPs) that further enable our control of t...
