Stachulski, Andrew V. Taujanskas, Joshua Pate, Sophie L. Rajoli, Rajith K. R. Aljayyoussi, Ghaith Pennington, Shaun H. Ward, Stephen A. Hong, Weiqian David Biagini, Giancarlo A. Owen, Andrew
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Published in
ACS Infectious Diseases
The rapidly growing COVID-19 pandemic is the most serious global health crisis since the “Spanish flu” of 1918. There is currently no proven effective drug treatment or prophylaxis for this coronavirus infection. While developing safe and effective vaccines is one of the key focuses, a number of existing antiviral drugs are being evaluated for thei...
Gorshkov, Kirill Chen, Catherine Z. Bostwick, Robert Rasmussen, Lynn Tran, Bruce Nguyen Cheng, Yu-Shan Xu, Miao Pradhan, Manisha Henderson, Mark Zhu, Wei
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Published in
ACS Infectious Diseases
Understanding the SARS-CoV-2 virus’ pathways of infection, virus–host–protein interactions, and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and design of new therapeutics to treat COVID-19. Chloroquine and hydroxychloroquine, extensively explored as clinical agents for COVID-19, have multiple cellular effects in...
Grover, Shipra Engelhart, Curtis A. Pérez-Herrán, Esther Li, Wei Abrahams, Katherine A. Papavinasasundaram, Kadamba Bean, James M. Sassetti, Christopher M. Mendoza-Losana, Alfonso Besra, Gurdyal S.
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Published in
ACS Infectious Diseases
MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis ( Mtb ), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targets and inhibit bacterial growth by more than one mechanism. Here, we describe a cell-based assay t...
Jílková, Adéla Horn, Martin Fanfrlík, Jindřich Küppers, Jim Pachl, Petr Řezáčová, Pavlína Lepšík, Martin Fajtová, Pavla Rubešová, Petra Chanová, Marta
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Published in
ACS Infectious Diseases
Azapeptide nitriles are postulated to reversibly covalently react with the active-site cysteine residue of cysteine proteases and form isothiosemicarbazide adducts. We investigated the interaction of azadipeptide nitriles with the cathepsin B1 drug target (SmCB1) from Schistosoma mansoni , a pathogen that causes the global neglected disease schisto...
Shang, Zifang Chan, Siew Yin Liu, William J. Li, Peng Huang, Wei
Published in
ACS Infectious Diseases
The SARS-CoV-2 outbreak that emerged at the end of 2019 has affected more than 58 million people with more than 1.38 million deaths and has had an incalculable impact on the world . Extensive prevention and treatment measures have been implemented since the pandemic. In this Review, we summarize current understanding on the source, transmission cha...
Mina, John G. M. Charlton, Rebecca L. Alpizar-Sosa, Edubiel Escrivani, Douglas O. Brown, Christopher Alqaisi, Amjed Borsodi, Maria Paula G. Figueiredo, Claudia P. de Lima, Emanuelle V. Dickie, Emily A.
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Published in
ACS Infectious Diseases
Current chemotherapeutics for leishmaniasis have multiple deficiencies, and there is a need for new safe, efficacious, and affordable medicines. This study describes a successful drug repurposing approach that identifies the over-the-counter antihistamine, clemastine fumarate, as a potential antileishmanial drug candidate. The screening for inhibit...
Soldano, Anabel Yao, Huili Punchi Hewage, Achala N. D. Meraz, Kevin Annor-Gyamfi, Joel K. Bunce, Richard A. Battaile, Kevin P. Lovell, Scott Rivera, Mario
Published in
ACS Infectious Diseases
Bacteria depend on a well-regulated iron homeostasis to survive adverse environments. A key component of the iron homeostasis machinery is the compartmentalization of Fe3+ in bacterioferritin and its subsequent mobilization as Fe2+ to satisfy metabolic requirements. In Pseudomonas aeruginosa Fe3+ is compartmentalized in bacterioferritin (BfrB), and...
Davies, Jonathan P. Almasy, Katherine M. McDonald, Eli F. Plate, Lars
Published in
ACS Infectious Diseases
Human coronaviruses (hCoVs) have become a threat to global health and society, as evident from the SARS outbreak in 2002 caused by SARS-CoV-1 and the most recent COVID-19 pandemic caused by SARS-CoV-2. Despite a high sequence similarity between SARS-CoV-1 and -2, each strain has a distinctive virulence. A better understanding of the basic molecular...
Dollman, Nicholas L. Griffin, Justin H. Downard, Kevin M.
Published in
ACS Infectious Diseases
A high resolution mass spectrometry approach has been applied for the first time to detect and characterize SARS-CoV-2 coronavirus in cell cultured and nasopharyngeal swab specimens. Peptide ions for three of the most abundant structural viral proteins (membrane, nucleocapid, and spike) are detected and assigned directly, by virtue of the high reso...
Sear, Claire E Pieper, Pauline Amaral, Maiara Romanelli, Maiara M Costa-Silva, Thais A Haugland, Marius M Tate, Joseph A Lago, João H G Tempone, Andre G Anderson, Edward A
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Published in
ACS infectious diseases
Trypanosoma cruzi is the etiologic agent of Chagas disease, which affects over seven million people, especially in developing countries. Undesirable side effects are frequently associated with current therapies, which are typically ineffective in the treatment of all stages of the disease. Here, we report the first synthesis of the neolignan dehydr...