Skrdla, Peter J. Yang, Husheng
Published in
AAPS PharmSciTech
Compared to more traditional top-down processing, the less common route to preparing drug nanocrystals through direct synthesis, e.g., starting with the nucleation of dissolved drug molecules (bottom-up processing), can offer both speed and cost advantages that makes it worthy of investigation. The current, theoretical work puts forth a technical b...
Shah, Harsh S. Chaturvedi, Kaushalendra Hamad, Mazen Bates, Simon Hussain, Ajaz Morris, Kenneth
Published in
AAPS PharmSciTech
Levothyroxine sodium pentahydrate (LEVO) tablets have been on the US market since the mid-twentieth century and remain the most highly prescribed product. Unfortunately, levothyroxine sodium tablets have also been one of the most highly recalled products due to potency and dissolution failures on stability. In 2008, the assay limits were tightened,...
Bastola, Rakesh Seo, Jo-Eun Noh, Gyubin Keum, Taekwang Kim, Ju Hun Shin, Jong Il Lee, Sooyeun Lee, Sangkil
Published in
AAPS PharmSciTech
We prepared mineral oil-based emulsion adjuvants by employing simple self-emulsifying drug delivery system (SEDDS). Mineral oil emulsions (3%, 5%, and 7%) were prepared using deionized water and C-971P NF and C-940 grade carbomer solutions with concentrations 0.01% (w/v) and 0.02% (w/v). In total, 15 emulsions were prepared and mixed with a solutio...
Prokopowicz, Magdalena Żeglinski, Jacek Szewczyk, Adrian Skwira, Adrianna Walker, Gavin
Published in
AAPS PharmSciTech
Here, we report an inorganic hexagonally ordered mesoporous fibre-like carrier made of silica as an effective drug delivery system with mineralisation potential. Fibre-like SBA-15 has been modified by employing a simple surface activation (rehydroxylation) procedure. The surface-rehydroxylated fibre-like SBA-15 (SBA-15-R) was used to investigate th...
Swarnakar, Nitin Kumar Venkatesan, Natarajan Betageri, Guru
Published in
AAPS PharmSciTech
Lipids have been extensively used in formulations to enhance dissolution and bioavailability of poorly water-soluble as well as water-soluble drug molecules. The digestion of lipid-based formulations, in the presence of bile salts, phospholipids, and cholesterol, changes the lipid composition in vivo, resulting in the formation of different colloid...
Shreya, A. B. Raut, Sushil Yadaorao Managuli, Renuka Suresh Udupa, Nayanabhirama Mutalik, Srinivas
Published in
AAPS PharmSciTech
The oral route is the most widely accepted and commonly used route for administration. However, this route may not be suitable for certain drug candidates which suffer from the problem of low aqueous solubility and gastrointestinal absorption and extensive first-pass effect. Nanotechnology-based approaches can be taken up as remedies to overcome th...
Benjasirimongkol, Pontip Piriyaprasarth, Suchada Moribe, Kunikazu Sriamornsak, Pornsak
Published in
AAPS PharmSciTech
In this study, the resveratrol spray-dried emulsions were developed using a quality-by-design approach. Further, the product and process factors that affected the quality of the spray-dried emulsions were analyzed and illustrated using an Ishikawa diagram. The product and process risks were prioritized using a risk-ranking system. The low methoxyl ...
Chittasupho, Chuda Posritong, Penpitcha Ariyawong, Pakaporn
Published in
AAPS PharmSciTech
The application of lutein was limited due to water insolubility and susceptible to heat and light degradation. In this study, hyaluronic acid (HA)-coated PLGA nanoparticles encapsulating lutein were fabricated by a solvent displacement method to improve the physicochemical properties and the stability of lutein. A biphasic release profile of lutein...
Nagy, Brigitta Farkas, Attila Borbás, Enikő Vass, Panna Nagy, Zsombor Kristóf Marosi, György
Published in
AAPS PharmSciTech
As the process analytical technology (PAT) mindset is progressively introduced and adopted by the pharmaceutical companies, there is an increasing demand for effective and versatile real-time analyzers to address the quality assurance challenges of drug manufacturing. In the last decades, Raman spectroscopy has emerged as one of the most promising ...
Peters, Johanna Taute, Wolfgang Döscher, Claas Höft, Michael Knöchel, Reinhard Breitkreutz, Jörg
Published in
AAPS PharmSciTech
Multi-resonance microwave sensors have recently been introduced for moisture monitoring of pharmaceutical particulates up to > 20% residual moisture. The extended measuring range compared to previous systems as well as the microwave moisture values independent of other physical attributes make them promising process analytical technology (PAT) tool...
