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Zirconium oxide ceramic foam: a promising supporting biomaterial for massive production of glial cell line-derived neurotrophic factor.

Authors
Type
Published Article
Journal
Journal of Zhejiang University. Science. B
Publication Date
Volume
15
Issue
12
Pages
1013–1022
Identifiers
DOI: 10.1631/jzus.B1400163
PMID: 25471830
Source
Medline
Keywords
  • Ceramic Foam
  • Glial Cell Line-Derived Neurotrophic Factor (Gdnf)
  • Parkinson’S Disease
  • Zirconium Oxide

Abstract

This study investigated the potential application of a zirconium oxide (ZrO2) ceramic foam culturing system to the production of glial cell line-derived neurotrophic factor (GDNF). Three sets of ZrO2 ceramic foams with different pore densities of 10, 20, and 30 pores per linear inch (PPI) were prepared to support a 3D culturing system. After primary astrocytes were cultured in these systems, production yields of GDNF were evaluated. The biomaterial biocompatibility, cell proliferation and activation of cellular signaling pathways in GDNF synthesis and secretion in the culturing systems were also assessed and compared with a conventional culturing system. In this study, we found that the ZrO2 ceramic foam culturing system was biocompatible, using which the GDNF yields were elevated and sustained by stimulated cell proliferation and activation of signaling pathways in astrocytes cultured in the system. In conclusion, the ZrO2 ceramic foam is promising for the development of a GDNF mass production device for Parkinson's disease treatment.

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