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Zinc-mediated one-pot tandem reaction of nitriles with propargyl bromides: an access to 3-alkynylpyridines.

Authors
  • He, Yan
  • Guo, Shenghai
  • Zhang, Xinying
  • Fan, Xuesen
Type
Published Article
Journal
The Journal of Organic Chemistry
Publisher
American Chemical Society
Publication Date
Nov 07, 2014
Volume
79
Issue
21
Pages
10611–10618
Identifiers
DOI: 10.1021/jo501869d
PMID: 25272335
Source
Medline
License
Unknown

Abstract

A one-pot procedure for the synthesis of 3-alkynylpyridines via a zinc-mediated tandem reaction of nitriles with propargyl bromides under extremely mild reaction conditions has been developed. This reaction exhibits high efficiency, broad substrate scope, and good functional group tolerance. In addition, the 3-alkynylpyridines obtained herein were found to be versatile and convenient intermediates for the preparation of fused-heterocyclic compounds with potential biological and material interests.

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