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Zinc deficiency and febrile seizure: a systematic review and meta-analysis.

Authors
  • Heydarian, Farhad1
  • Nakhaei, Alireza Ataei1
  • Majd, Hasan Mehrad2
  • Bakhtiari, Elham3
  • 1 Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 2 Department of Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 3 Department of Eye Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
Type
Published Article
Journal
The Turkish Journal of Pediatrics
Publisher
The Turkish Journal of Pediatrics
Publication Date
Jan 01, 2020
Volume
62
Issue
3
Pages
347–358
Identifiers
DOI: 10.24953/turkjped.2020.03.001
PMID: 32558408
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Zinc has been reported to be low in children with febrile seizure compared to febrile cases without seizures, but results are inconsistent. A meta-analysis was performed to systematically evaluate the serum level of zinc in febrile children aged between 6-72 months with or without seizures. A systematic search of databases was performed from January 2000 to January 2019. Studies comparing the serum level of zinc in febrile children with or without seizure were selected. The major outcome was serum level of zinc. Random effect model was used to calculate pooled standardized mean differences (SMD) with 95% confidence intervals (CIs). A total of 31 articles were included. Meta-analysis suggested that the serum level of zinc is lower in patients with febrile seizure versus febrile cases without seizure (SMD: -1.2, 95%CI= (-1.47, -0.93). In subgroup and sensitivity analysis no significant change was observed in pooled SMD. In meta-regression analysis sample size as a continuous variable had a significant influence on between-study variance (p= 0.02). According to cumulative analysis the difference of serum level of zinc in febrile children with or without seizure decreased with time. This meta-result indicated a significant association of zinc deficiency with seizure in febrile children. It is suspected that decreased level of zinc may be involved in seizure occurrences and it may play a role in the pathogenesis of febrile seizure.

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