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Zeolitic imidazolate framework-based biosensor for detection of HIV-1 DNA.

Authors
  • Pan, Yong1
  • Zhan, Shenshan2
  • Xia, Fan3
  • 1 Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, China. Electronic address: [email protected] , (China)
  • 2 Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, China. , (China)
  • 3 Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, China; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Analytical Biochemistry
Publisher
Elsevier
Publication Date
Apr 01, 2018
Volume
546
Pages
5–9
Identifiers
DOI: 10.1016/j.ab.2018.01.017
PMID: 29382468
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

ZIF-8(zinc-methylimidazolate framework-8), one of the zeolitic imidazolate frameworks (ZIFs), as quenching platforms for detection of HIV-1 DNA, which was identified to be effective for highly sensitive detection of HIV-1 DNA. The enhanced fluorescence signal has a relationship with the ssDNA concentration, the detection limit is as low as 1.2 nmol L-1 with good selectivity. This study is an important step toward rational design of materials to achieve specific interactions between biomolecules and synthetic particle surfaces. Copyright © 2018. Published by Elsevier Inc.

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