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Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants

Authors
  • Modarresi Chahardehi, Amir
  • Arsad, Hasni
  • Lim, Vuanghao
Type
Published Article
Journal
Plants
Publisher
MDPI AG
Publication Date
Oct 12, 2020
Volume
9
Issue
10
Identifiers
DOI: 10.3390/plants9101345
PMID: 33053800
PMCID: PMC7601530
Source
PubMed Central
Keywords
License
Green

Abstract

The zebrafish ( Danio rerio ) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput manner. The zebrafish embryotoxicity model is at the leading edge of toxicology research due to the short time required for analyses, transparency of embryos, short life cycle, high fertility, and genetic data similarity. Zebrafish toxicity studies range from assessing the toxicity of bioactive compounds or crude extracts from plants to determining the optimal process. Most of the studied extracts were polar, such as ethanol, methanol, and aqueous solutions, which were used to detect the toxicity and bioactivity. This review examines the latest research using zebrafish as a study model and highlights its power as a tool for detecting toxicity of medicinal plants and its effectiveness at enhancing the understanding of new drug generation. The goal of this review was to develop a link to ethnopharmacological zebrafish studies that can be used by other researchers to conduct future research.

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