Affordable Access

deepdyve-link deepdyve-link
Publisher Website

The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17.

Authors
  • McGlinchey, Ryan P
  • Yap, Thai Leong
  • Lee, Jennifer C
Type
Published Article
Journal
Physical Chemistry Chemical Physics
Publisher
The Royal Society of Chemistry
Publication Date
Dec 07, 2011
Volume
13
Issue
45
Pages
20066–20075
Identifiers
DOI: 10.1039/c1cp21376h
PMID: 21993592
Source
Medline
License
Unknown

Abstract

Amyloid has been traditionally viewed in the context of disease. However, the emerging concept of 'functional amyloid' has taken a new direction into how we view amyloid. Recent studies have identified amyloid fibrils ranging from bacteria to humans that have a beneficial role, instead of being associated with a misfolded state that has been implicated in diseases such as Alzheimer's, Parkinson's and prion diseases. Here, we review our work on two human amyloidogenic polypeptides, one associated with Parkinson's disease, α-synuclein (α-syn), and the other important for melanin synthesis, the repeat domain (RPT) from Pmel17. Particularly, we focused our attention on spectroscopic studies of protein conformation and dynamics and their impact on α-syn amyloid formation and for RPT, we discussed the strict pH dependence of amyloid formation and its role in melanin biosynthesis.

Report this publication

Statistics

Seen <100 times