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Yersinia pseudotuberculosis Adhesins Regulate Tissue-Specific Colonization and Immune Cell Localization in a Mouse Model of Systemic Infection▿ †

Authors
  • Krischan J. Hudson
  • Amy H. Bouton
Publisher
American Society for Microbiology
Publication Date
Aug 18, 2006
Source
PMC
Keywords
License
Unknown

Abstract

Yersinia pseudotuberculosis mutants deficient for the adhesins invasin and/or YadA were injected intravenously into BALB/c mice. Invasin expression inhibited colonization of the liver and spleen. YadA decreased liver colonization but promoted growth within the lung. The persistence of leukocytes within liver microabscesses correlated with enhanced colonization and lack of adhesin expression.

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