Affordable Access

The YAL017 gene on the left arm of chromosome I of Saccharomyces cerevisiae encodes a putative serine/threonine protein kinase.

Authors
  • Clark, M W
  • Zhong, W W
  • Keng, T
  • Storms, R K
  • Ouellette, B F
  • Barton, A
  • Kaback, D B
  • Bussey, H
Type
Published Article
Journal
Yeast (Chichester, England)
Publication Date
May 01, 1993
Volume
9
Issue
5
Pages
543–549
Identifiers
PMID: 8322517
Source
Medline
License
Unknown

Abstract

The DNA sequence of a region between the LTE1 and CYS3 genes on the left arm of chromosome I from Saccharomyces cerevisiae contains an open reading frame (ORF), YAL017, corresponding to the 5.0 kb FUN31 (Function Unknown Now) transcribed region. The predicted protein from this ORF contains 1358 amino acid residues with a molecular weight of 152,531, and an identifiable serine/threonine protein kinase catalytic domain. When compared with other yeast protein kinases, the Yal017p kinase most resembles the SNF1 serine/threonine protein kinase which is involved in regulating sucrose fermentation genes. The Yal017p kinase shows highest amino acid identities with two mammalian carcinoma-related serine/threonine protein kinases; PIM-1, which shows induced expression in T-cell lymphomas; and p78A1, whose expression is lost in human pancreatic carcinomas. Gene disruption of YAL017 indicates that it is non-essential for growth on glucose.

Report this publication

Statistics

Seen <100 times