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X-ray-induced shortwave infrared luminescence computed tomography.

Authors
  • Dai, Xianjin
  • Cheng, Kai
  • Zhao, Wei
  • Xing, Lei
Type
Published Article
Journal
Optics Letters
Publisher
The Optical Society
Publication Date
Oct 01, 2019
Volume
44
Issue
19
Pages
4769–4772
Identifiers
DOI: 10.1364/OL.44.004769
PMID: 31568438
Source
Medline
Language
English
License
Unknown

Abstract

X-ray luminescence computed tomography (XLCT) based on x-ray-excitable nanophosphors has been proposed as a new modality for molecular imaging. The technique has two main advantages compared to other modalities. First, autofluorescence, which is problematic for fluorescence imaging, can be substantially reduced. Second, deep-tissue in vivo imaging with high optical contrast and spatial resolution becomes achievable. Here, we extend the novel XLCT modality from the visible or infrared region to a shortwave infrared wavelength by developing an x-ray-induced shortwave infrared luminescence computed tomography (SWIR-XLCT). For this application, rare-earth nanophosphors (RENPs) were synthesized as core/shell structures consisting of a Ho-doped NaYbF4 core surrounded by a NaYF4 shell that emit light efficiently in the shortwave infrared spectral region under x-ray excitation. Through numerical simulations and phantom experiments, we showed the feasibility of SWIR-XLCT and demonstrated its potential for x-ray luminescence imaging with high spatial resolution and deep depth.

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