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X-chromosome inactivation: closing in on proteins that bind Xist RNA.

Authors
  • Brockdorff, Neil
Type
Published Article
Journal
Trends in Genetics
Publisher
Elsevier
Publication Date
Jul 01, 2002
Volume
18
Issue
7
Pages
352–358
Identifiers
PMID: 12127775
Source
Medline
License
Unknown

Abstract

X inactivation is the developmentally regulated silencing of a single X chromosome in XX female mammals. In recent years, the Xist gene has been revealed as the master regulatory switch controlling this process. Parental imprinting and/or counting mechanisms ensure that Xist is expressed only on the inactive X chromosome. Chromosome silencing then results from the accumulation of the Xist RNA silencing signal, in cis, over the entire length of the X chromosome. A key issue has been to identify the factors that interact with Xist RNA to initiate heritable gene silencing. This review discusses recent progress that has put this goal in sight.

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