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WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

Authors
  • Tsurumi, Y
  • Ohhata, N
  • Iwamoto, T
  • Shigematsu, N
  • Sakamoto, K
  • Nishikawa, M
  • Kiyoto, S
  • Okuhara, M
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Jun 01, 1994
Volume
47
Issue
6
Pages
619–630
Identifiers
PMID: 8040066
Source
Medline
License
Unknown

Abstract

WS79089A, B and C, which are novel endothelin converting enzyme (ECE) inhibitors have been isolated from the fermentation broth of Streptosporangium roseum No. 79089. These inhibitors were purified from an acetone extract of whole culture broth followed by Silicar CC-4 column chromatography and HPLC. WS79089A, B and C showed highly selective ECE inhibition activity with IC50 values of 0.73 microM 0.14 microM and 3.42 microM, respectively. On the basis of spectroscopic and chemical evidence, the tentative structures of WS79089A, B and C have been proposed, they have benzo[a]naphtacen chromophores.

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