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Wound Healing Activity of Arum Maculatum

Authors
  • ARZU SAKUL, Ayse1
  • OKUR, Mehmet Evren2
  • AYLA, Sule3
  • DAYLAN, Benay4
  • KARADAG, Ayse Esra5
  • BATUR, Sebnem6
  • OZDEMIR, Ekrem Musa7
  • ALTINALAN, Ebrar1
  • GUNAL, Mehmet Yalcin8
  • 1 Istanbul Medipol University Faculty of Medicine, Department of Medical Pharmacology; Research Institute for Health Sciences and Technologies (SABITA), Istanbul, Turkey
  • 2 University of Health Sciences Faculty of Pharmacy, Department of Pharmacology, Istanbul, Turkey
  • 3 Istanbul Medeniyet University Faculty of Medicine, Department of Histology and Embryology, Istanbul, Turkey
  • 4 Istanbul Medipol University Faculty of Medicine, Department of Histology and Embryology, Istanbul, Turkey
  • 5 Istanbul Medipol University Faculty of Pharmacy, Department of Pharmacognosy, Istanbul, Turkey
  • 6 Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pathology, Istanbul, Turkey
  • 7 Istanbul Medipol University, Research Institute for Health Sciences and Technologies (SABITA); Medical Research Center (MEDITAM), Istanbul, Turkey
  • 8 Alanya Alaaddin Keykubat University Faculty of Medicine, Department of Physiology, Antalya, Turkey
Type
Published Article
Journal
Medeniyet Medical Journal
Publisher
Galenos Publishing
Publication Date
Mar 27, 2023
Volume
38
Issue
1
Pages
8–15
Identifiers
DOI: 10.4274/MMJ.galenos.2022.73368
PMID: 36974384
PMCID: PMC10064101
Source
PubMed Central
Keywords
Disciplines
  • Original Article
License
Unknown

Abstract

Objective In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed to assess and determine the possible pharmacological activities of A. maculatum and evaluate its potential to act as a wound care plant. Methods The antioxidant and antimicrobial activities of A. maculatum were investigated using excisional in vivo and in vitro wound healing mouse models. A total of 32 Balb-c mice were used, which were equally, divided into four groups: saline control group, control group, A. maculatum group, and Centella asiatica extract group. Treatment applications were performed topically once per day. Wound area narrowing, wound healing percentage, and epithelialization time were analyzed. Results A. maculatum application supported the healing process in in vivo and in vitro wound models. A. maculatum contributed to the healing process by promoting granulation tissue formation, epidermal regeneration, and angiogenesis. Conclusions Wound healing is a complex and well-organized process that requires communication between cells. The antioxidant and antimicrobial activities of A. maculatum extract have been determined by current studies. A. maculatum extract may provide significant benefits in promoting the wound healing process.

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