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Working principles in the immune system implied by the "peptidic self" model.

Authors
  • P Kourilsky
  • G Chaouat
  • C Rabourdin-Combe
  • J M Claverie
Publication Date
May 01, 1987
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

The hypothesis that self as well as foreign proteins are processed into peptides and presented by major histocompatibility complex antigens leads to a set of working principles that could govern cellular interactions in immune responses. In particular, "idiopeptides," derived from immunoglobulins and T-cell receptors and recognized by appropriate T cells, are expected to play an important regulatory role. We show here that these speculations fit into a consistent view of the immune system.

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