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Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche.

Authors
  • Wang, Xiaoxi1
  • Page-McCaw, Andrea2
  • 1 Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
  • 2 Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA [email protected]
Type
Published Article
Journal
Development
Publisher
The Company of Biologists
Publication Date
Feb 07, 2018
Volume
145
Issue
3
Identifiers
DOI: 10.1242/dev.158527
PMID: 29361569
Source
Medline
Keywords
License
Unknown

Abstract

Stem cells reside in a niche, a local environment whose cellular and molecular complexity is still being elucidated. In Drosophila ovaries, germline stem cells depend on cap cells for self-renewing signals and physical attachment. Germline stem cells also contact the anterior escort cells, and here we report that anterior escort cells are absolutely required for germline stem cell maintenance. When escort cells die from impaired Wnt signaling or hid expression, the loss of anterior escort cells causes loss of germline stem cells. Anterior escort cells function as an integral niche component by promoting DE-cadherin anchorage and by transiently expressing the Dpp ligand to promote full-strength BMP signaling in germline stem cells. Anterior escort cells are maintained by Wnt6 ligands produced by cap cells; without Wnt6 signaling, anterior escort cells die leaving vacancies in the niche, leading to loss of germline stem cells. Our data identify anterior escort cells as constituents of the germline stem cell niche, maintained by a cap cell-produced Wnt6 survival signal.

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